Immuno-capture of extracellular vesicles for individual multi-modal characterization using AFM, SEM and Raman spectroscopy

P Beekman, A Enciso-Martinez, HS Rho, SP Pujari… - Lab on a Chip, 2019 - pubs.rsc.org
Tumor-derived extracellular vesicles (tdEVs) are promising blood biomarkers for cancer
disease management. However, blood is a highly complex fluid that contains multiple …

An integrated sample-to-answer SERS platform for multiplex phenotyping of extracellular vesicles

W Lin, L Yuan, Z Gao, G Cai, C Liang, M Fan… - Sensors and Actuators B …, 2023 - Elsevier
Tumor-derived extracellular vesicles (EVs) are emerging as a non-invasive liquid biopsy
marker for cancer diagnosis and treatment monitoring. However, clinical detection …

Dual imaging single vesicle surface protein profiling and early cancer detection

K Amrhein, ML Taylor, R Wilson… - … applied materials & …, 2023 - ACS Publications
Single vesicle molecular profiling has the potential to transform cancer detection and
monitoring by precisely probing cancer-associated extracellular vesicles (EVs) in the …

Enabling sensitive phenotypic profiling of cancer-derived small extracellular vesicles using surface-enhanced Raman spectroscopy nanotags

W Zhang, L Jiang, RJ Diefenbach, DH Campbell… - ACS …, 2020 - ACS Publications
Circulating cancer-derived small extracellular vesicles (EVs) are nanoscale membranous
vesicles shed from cancer cells that are released into surrounding body fluids. Small EVs …

Single molecule characterization of individual extracellular vesicles from pancreatic cancer

KM Lennon, DL Wakefield, AL Maddox… - Journal of …, 2019 - Taylor & Francis
Biofluid-accessible extracellular vesicles (EVs) may represent a new means to improve the
sensitivity and specificity of detecting disease. However, current methods to isolate EVs …

EV-Ident: identifying tumor-specific extracellular vesicles by size fractionation and single-vesicle analysis

D Kim, HK Woo, C Lee, Y Min, S Kumar… - Analytical …, 2020 - ACS Publications
Tumor-derived extracellular vesicles (EVs) have emerged as a promising source of
circulating biomarkers for liquid biopsies. However, understanding the heterogeneous …

Isolation and digital counting of extracellular vesicles from blood via membrane-integrated microfluidics

YS Chen, C Chen, CPK Lai, GB Lee - Sensors and Actuators B: Chemical, 2022 - Elsevier
Extracellular vesicles (EVs), existing in body fluids, have exhibited a significant potential in
clinical diagnostics since many harbor biomarkers specific to certain diseases. Therefore …

Extracellular vesicle-based liquid biopsy biomarkers and their application in precision immuno-oncology

K Asleh, V Dery, C Taylor, M Davey… - Biomarker …, 2023 - Springer
While the field of precision oncology is rapidly expanding and more targeted options are
revolutionizing cancer treatment paradigms, therapeutic resistance particularly to …

Rapid capture of cancer extracellular vesicles by lipid patch microarrays

HY Liu, R Kumar, C Zhong, S Gorji… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) contain various bioactive molecules such as DNA, RNA, and
proteins, and play a key role in the regulation of cancer progression. Furthermore, cancer …

Bio-inspired nanovilli chips for enhanced capture of tumor-derived extracellular vesicles: toward non-invasive detection of gene alterations in non-small cell lung …

J Dong, RY Zhang, N Sun, M Smalley… - … applied materials & …, 2019 - ACS Publications
Tumor-derived extracellular vesicles (EVs) present in bodily fluids are emerging liquid
biopsy markers for non-invasive cancer diagnosis and treatment monitoring. Because the …