Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Y Nazerian, M Ghasemi, Y Yassaghi, A Nazerian… - International …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) outbreak has become a global public health
emergency and has led to devastating results. Mounting evidence proposes that the disease …

Coronavirus 2019 disease (COVID‐19), systemic inflammation, and cardiovascular disease

RM Inciardi, SD Solomon, PM Ridker… - Journal of the American …, 2020 - Am Heart Assoc
(SARS-CoV-2), has rapidly spread worldwide and presents critical challenges for the public
health and medical communities. The World Health Organization has declared SARS-CoV-2 …

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …

COVID-19 and multiorgan response

S Zaim, JH Chong, V Sankaranarayanan… - Current problems in …, 2020 - Elsevier
Since the outbreak and rapid spread of COVID-19 starting late December 2019, it has been
apparent that disease prognosis has largely been influenced by multiorgan involvement …

[HTML][HTML] Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

M Soy, G Keser, P Atagündüz, F Tabak… - Clinical …, 2020 - Springer
COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes
only mild symptoms in the majority of the cases, while immunologic complications such as …

[HTML][HTML] Calming the storm: natural immunosuppressants as adjuvants to target the cytokine storm in COVID-19

AE Peter, BV Sandeep, BG Rao… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat
the infection and the absence of a suitable vaccine to prevent it. While some individuals …

Cytokine release syndrome: inhibition of pro-inflammatory cytokines as a solution for reducing COVID-19 mortality

N Moradian, M Gouravani, MA Salehi, A Heidari… - European cytokine …, 2020 - Springer
Abstract Coronavirus disease (COVID-19) reached pandemic proportions at the beginning
of 2020 and continues to be a worldwide concern. End organ damage and acute respiratory …

Is the kidney a target of SARS-CoV-2?

MA Martinez-Rojas, O Vega-Vega… - American Journal of …, 2020 - journals.physiology.org
The new disease produced by severe acute respiratory syndrome-coronavirus 2 (SARS-
CoV-2) represents a major pandemic event nowadays. Since its origin in China in …

[HTML][HTML] The COVID-19 cytokine storm; what we know so far

D Ragab, H Salah Eldin, M Taeimah… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the
WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract …

[HTML][HTML] Macrophage activation syndrome and COVID-19

R Otsuka, K Seino - Inflammation and regeneration, 2020 - Springer
An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating
pandemic. As we have not developed curative medicine and effective vaccine, the end of …