A new series of chalcones 5a–f were synthesized from caffeine-based aldehyde 3 and
substituted acetophenones 4a–f. Treatment of compounds 5a–f with hydrazine hydrate led …

An optimization of a modified Grimmel's method for N-heterocyclization of Leucine linked
sulphonamide leading to 2, 3-disustituted-4-quinazolin-(3 H)-ones was accomplished …

A series of novel keto-enamine chalcone-chloroquine based hybrids were synthesized
following new methodology developed in our laboratory. The synthesized compounds were …

Abstract A series of 1H-1, 2, 3-triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-
indole-7-chloroquinoline conjugates have been synthesized and evaluated for their …

Background Malaria extensively leads to mortality and morbidity in endemic regions, and the
emergence of drug resistant parasites is alarming. Plant derived synthetic pharmaceutical …

A series of pyrazole-pyrazoline substituted with benzenesulfonamide were synthesized and
evaluated for their antimalarial activity in vitro and in vivo. The compounds were active …

Abstract A series of novel 1, 3, 5-trisubstituted pyrazolines derivatives have been
synthesized from chalcones and nicotinic acid hydrazide in two steps. In first step, chalcones …

Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

The importance of American trypanosomiasis (Chagas' disease) in human pathology is
widely known. The prognosis of this disease is poor and the choice of effective medicines …

A series of novel 4-aminoquinoline-pyrimidine hybrids has been synthesized and evaluated
for their antimalarial activity. Several compounds showed promising in vitro antimalarial …