Epigenetic clocks, developed using DNA methylation data, have been widely used to
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …

Background Identifying biological pathways that vary across the age spectrum can provide
insight into fundamental mechanisms that impact disease and frailty in the elderly. Few …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Genome-wide studies of aging have identified subsets of genes that show age-related
changes in expression. Although the types of genes that are age regulated vary among …

It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …

Aging is the biggest risk factor for cancer, but the mechanisms linking these two processes
remain unclear. Using GTEx and TCGA data, we compared genes differentially expressed …

Abstract GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …

Biological age captures a person's age-related risk of unfavorable outcomes using
biophysiological information. Multivariate biological age measures include frailty scores and …