Aging is the single largest risk factor for chronic disease. Studies in model organisms have
identified conserved pathways that modulate aging rate and the onset and progression of …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Cellular senescence, an integral component of aging and cancer, arises in response to
diverse triggers, including telomere attrition, macromolecular damage and signaling from …

To define metrics of phenotypic aging, it is essential to identify biological and environmental
factors that influence the pace of aging. Previous attempts to develop aging metrics were …

The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …

Background A person's rate of aging has important implications for his/her risk of death and
disease; thus, quantifying aging using observable characteristics has important applications …

Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …

Because people age differently, age is not a sufficient marker of susceptibility to disabilities,
morbidities, and mortality. We measured nineteen blood biomarkers that include …