The structural features determining efficient biosynthesis, stability in the membrane and,
after solubilization, in detergents are not well understood for integral membrane proteins …

G protein-coupled receptors (GPCRs) are flexible integral membrane proteins involved in
transmembrane signaling. Their involvement in many physiological processes makes them …

To identify structural features in a G‐protein‐coupled receptor (GPCR) crucial for
biosynthesis, stability in the membrane and stability in detergent micelles, we developed an …

Structural and biophysical studies as well as drug screening approaches on G protein-
coupled receptors (GPCRs) have been largely hampered by the poor biophysical properties …

G protein-coupled receptors (GPCRs) are integral membrane proteins that can convert an
extracellular signal into multiple intracellular signaling processes. This pleiotropy of GPCRs …

The second extracellular loop: a damper for G protein–coupled receptors? | Nature Structural
& Molecular Biology Skip to main content Thank you for visiting nature.com. You are using a …

Mutations of GPCRs can increase their constitutive (agonist-independent) activity. Some of
these mutations have been artificially introduced by site-directed mutagenesis; others occur …

G-protein-coupled receptors (GPCRs) are cell-surface receptors exhibiting a key role in
cellular signal transduction processes, thus making them pharmacologically highly relevant …

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and are
important human drug targets. Of the 826 human GPCRs, 118 of them recognize …

Ste2p, the G protein-coupled receptor (GPCR) for the tridecapeptide pheromone α-factor of
Saccharomyces cerevisiae, was used as a model GPCR to investigate the role of specific …