Sepsis is recognized as a life‐threatening organ dysfunctional disease that is caused by
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to
infection, is a leading cause of death in intensive care units. The development of sepsis …

The inflammatory response is one of the host's mechanisms to combat pathogens. Normal
and controlled inflammation can accelerate the clearance of pathogens. However, in sepsis …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …

Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Sepsis is defined as a life‐threatening disease involving multiple organ dysfunction caused
by dysregulated host responses to infection. To date, sepsis remains a dominant cause of …

Immune cells and skin and mucosal epithelial cells recognize invasive microbes and other
signs of danger to sound alarms that recruit responder cells and initiate an immediate …

Programmed cell death has crucial roles in the physiological maturation of an organism, the
maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed …

Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …

Abstract Purpose Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the
gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a …