Intramolecular cascade cyclization via photogenerated N-amidyl radicals toward isoindolin-1-one/3, 4-dihydroisoquinolin-1 (2 H)-one fused oxazinane

YX He, K Hu, Y Ran, ZY Lei, S Geng… - Organic Chemistry …, 2023 - pubs.rsc.org
Based on the importance of the two classes of nitrogen-containing heterocyclic structures,
isoindolinones and isoquinolinones, herein, through intramolecular cascade cyclization via …

Visible-light-induced intramolecular radical cascade of α-bromo-N-benzyl-alkylamides: A new strategy to synthesize tetracyclic N-fused indolo [2, 1-a] isoquinolin-6 (5 …

X Gao, C Li, Y Yuan, X Xie, Z Zhang - Organic & Biomolecular …, 2020 - pubs.rsc.org
Polycyclic indole scaffolds are ubiquitous in pharmaceuticals and natural products and in
materials science. Here, we present a visible-light-initiated intramolecular aryl migration …

Visible light-induced N-radical 5-exo/6-endo cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinones

ZY Lei, K Hu, YX He, S Geng, LN Chen… - Organic & …, 2022 - pubs.rsc.org
An efficient N-centered radical intramolecular cyclization reaction of alkenyl amides induced
by visible light was described. In this process, an alkenyl amide underwent 5-exo/6-endo …

Synthesis of indolo [2, 1-α] isoquinoline derivatives via metal-free radical cascade cyclization

XY Hu, HF Xu, Q Chen, YL Pan, JZ Chen - Organic & Biomolecular …, 2021 - pubs.rsc.org
In the present studies, we describe a convenient and efficient protocol for the synthesis of
the indolo [2, 1-α] isoquinoline core structure through the reaction of 2-aryl-N-acryloyl …

Electrochemical 5-exo-dig aza-cyclization of 2-alkynylbenzamides toward 3-hydroxyisoindolinone derivatives

Z Shi, N Li, WZ Wang, HK Lu, Y Yuan, Z Li… - Organic & Biomolecular …, 2022 - pubs.rsc.org
Preparation of biologically relevant 3-hydroxyisoindolinones from readily available 2-
alkynylbenzamides is an appealing synthetic approach. However, such kinds of compounds …

Copper-catalyzed amino radical tandem cyclization toward the synthesis of indolo-[2, 1-a] isoquinolines

ML Liu, JL Wang, XS Li, WH Sun, XY Liu - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
We report a convenient process for synthesizing indolo-[2, 1-a] isoquinoline tetracyclic
skeletons in one pot via a low-cost copper-catalyzed tandem amino radical cyclization, in …

Tunable Synthesis of 3-Hydroxylisoquinolin-1,4-dione and Isoquinolin-1-one Enabled by Copper-Catalyzed Radical 6-endo Aza-cyclization of 2-Alkynylbenzamide

R Liu, M Li, W Xie, H Zhou, Y Zhang… - The Journal of Organic …, 2019 - ACS Publications
In this work, switchable synthesis of isoquinolin-1-one and 3-hydroxylisoquinolin-1, 4-dione
from 2-alkynylbenzamide is reported. The transformation works well with good yields and a …

Hydroxyalkylation-Initiated Radical Cyclization of N-Allylbenzamide for Direct Construction of Isoquinolinone

W Zhou, S Ni, H Mei, J Han, Y Pan - Organic letters, 2015 - ACS Publications
A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction
of N-allylbenzamide is developed. This reaction proceeds through C (sp3)–H bond …

Synthesis of O-Heterocycle Spiro-Fused Cyclopentaquinolinones and Cyclopentaindenes through Visible Light-Induced Radical Cyclization Reactions

L Xue, X Song, X Zhang, X Fan - The Journal of Organic …, 2023 - ACS Publications
Presented herein is an effective and sustainable synthesis of O-heterocycle spiro-fused
cyclopentaquinolinone and cyclopentaindene derivatives through light-driven cascade …

Photoredox-catalyzed direct aminoalkylation of isatins: diastereoselective access to 3-hydroxy-3-aminoalkylindolin-2-ones analogues

CM Wang, D Song, PJ Xia, ZP Ye, JA Xiao… - Organic Chemistry …, 2018 - pubs.rsc.org
A practical protocol for the direct aminoalkylation of isatins with tetrahydroisoquinolines and
other amines via a photoredox catalyzed radical–radical cross-coupling process is …