Structural and functional analyses of activating amino acid substitutions in the receiver domain of NtrC: evidence for an activating surface
The bacterial enhancer-binding protein NtrC activates transcription when phosphorylated on
aspartate 54 in its amino (N)-terminal regulatory domain or when altered by constitutively …
aspartate 54 in its amino (N)-terminal regulatory domain or when altered by constitutively …
Phosphorylation-induced signal propagation in the response regulator NtrC
The bacterial enhancer-binding protein NtrC is a well-studied response regulator in a two-
component regulatory system. The amino (N)-terminal receiver domain of NtrC modulates …
component regulatory system. The amino (N)-terminal receiver domain of NtrC modulates …
Phosphorylation-independent dimer-dimer interactions by the enhancer-binding activator NtrC of Escherichia coli: a third function for the C-terminal domain
The response regulator NtrC transcriptionally activates genes of the nitrogen-regulated (Ntr)
response. Phosphorylation of its N-terminal receiver domain stimulates an essential …
response. Phosphorylation of its N-terminal receiver domain stimulates an essential …
Mechanism of activation of a response regulator: interaction of NtrC-P dimers induces ATPase activity
I Mettke, U Fiedler, V Weiss - Journal of bacteriology, 1995 - Am Soc Microbiol
NtrC is the transcriptional activator for nitrogen-regulated promoters and, as a response
regulator, belongs to the protein family of two-component systems. The activity of all …
regulator, belongs to the protein family of two-component systems. The activity of all …
Identification of Linker Regions and Domain Borders of the Transcription Activator Protein NtrC from Escherichia coli by Limited Proteolysis, In-Gel Digestion, and …
M Bantscheff, V Weiss, MO Glocker - Biochemistry, 1999 - ACS Publications
We have developed a mass spectrometry based method for the identification of linker
regions and domain borders in multidomain proteins. This approach combines limited …
regions and domain borders in multidomain proteins. This approach combines limited …
Physical evidence for a phosphorylation-dependent conformational change in the enhancer-binding protein NtrC
The bacterial enhancer-binding protein nitrogen regulatory protein C (NtrC) activates
transcription by σ54-containing RNA polymerase in a reaction that depends on ATP …
transcription by σ54-containing RNA polymerase in a reaction that depends on ATP …
Effector‐induced self‐association and conformational changes in the enhancer‐binding protein NTRC
ME Farez‐Vidal, TJ Wilson, BE Davidson… - Molecular …, 1996 - Wiley Online Library
The Klebsiella pneumoniae nitrogen regulatory protein NTRC is a response regulator which
activates transcription in response to nitrogen limitation, and is a member of the family of σN …
activates transcription in response to nitrogen limitation, and is a member of the family of σN …
“Switch I” mutant forms of the bacterial enhancer-binding protein NtrC that perturb the response to DNA
D Yan, S Kustu - Proceedings of the National Academy of …, 1999 - National Acad Sciences
NtrC (nitrogen regulatory protein C) is a bacterial enhancer-binding protein of 469 residues
that activates transcription by σ54-holoenzyme. A region of its transcriptional activation …
that activates transcription by σ54-holoenzyme. A region of its transcriptional activation …
Molecular dynamic simulations of the N-terminal receiver domain of NtrC reveal intrinsic conformational flexibility in the inactive state
X Hu, Y Wang - Journal of Biomolecular Structure and Dynamics, 2006 - Taylor & Francis
The N-terminal receiver domain of NtrC is the molecular switch in the two-component signal
transduction. It is the first protein where structures of both the active (phosphyroylated) and …
transduction. It is the first protein where structures of both the active (phosphyroylated) and …
The phosphorylated form of the enhancer-binding protein NTRC has an ATPase activity that is essential for activation of transcription
The NTRC protein of enteric bacteria is an enhancerbinding protein that activates
transcription in response to limitation of combined nitrogen. NTRC activates transcription by …
transcription in response to limitation of combined nitrogen. NTRC activates transcription by …