Models describing the process of stem-cell differentiation are plentiful, and may offer insights
into the underlying mechanisms and experimentally observed behaviour. Waddington's …

Understanding cell fate selection remains a central challenge in developmental biology. We
present a class of simple yet biologically motivated mathematical models for cell …

Background The image of the" epigenetic landscape", with a series of branching valleys and
ridges depicting stable cellular states and the barriers between those states, has been a …

Phenotypic evolutionary models have been used with great success in many areas of
biology, but thus far have not been applied to the study of stem cells except for investigations …

Recent breakthroughs of cell phenotype reprogramming impose theoretical challenges on
unravelling the complexity of large circuits maintaining cell phenotypes coupled at many …

Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the
relationship between gene activity and cell fates during development. Over the past few …

Waddington epigenetic landscape, as a classic metaphor, has been used to explain cellular
development and differentiation. However, it remains challenging to quantify the epigenetic …

The well-known Waddington's epigenetic landscape of cell-fate determination is not static
but varies because of the dynamic gene regulation during development. However, existing …

Stem cells have the capability to self-renew and maintain their undifferentiated state or to
differentiate into one or more specialised cell types. Stem cell expansion and manipulation …

Multipotent stem or progenitor cells undergo a sequential series of binary fate decisions,
which ultimately generate the diversity of differentiated cells. Efforts to understand cell fate …