The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines
DM Loeb, J Maragos, D Martin-Zanca, MV Chao… - Cell, 1991 - cell.com
The trk tyrosine kinase proto-oncogene product gp140p'“'o” k binds nerve growth factor
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …
The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
C Cordon-Cardo, P Tapley, S Jing, V Nanduri… - Cell, 1991 - cell.com
The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF).
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …
The trk proto-oncogene encodes a receptor for nerve growth factor
R Klein, S Jing, V Nanduri, E O'Rourke, M Barbacid - Cell, 1991 - cell.com
Two classes of receptors with distinct affinities for nerve growth factor (NGF) have been
identified. The low affinity receptor (Kd-= 10. 9 to 10-aM) is a cysteinerich glycoprotein …
identified. The low affinity receptor (Kd-= 10. 9 to 10-aM) is a cysteinerich glycoprotein …
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
R Klein, V Nanduri, S Jing, F Lamballe, P Tapley… - Cell, 1991 - cell.com
Summary trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …
The trk family of oncogenes and neurotrophin receptors.
F Lamballe, R Klein, M Barbacid - Princess Takamatsu symposia, 1991 - europepmc.org
To date more than twenty five different oncogenes have been identified in human
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
BL Hempstead, SJ Rabin, L Kaplan, S Reid, LF Parada… - Neuron, 1992 - cell.com
To investigate the role of the gp140trk receptor tyrosine kinase in nerve growth factor (NCF)-
induced differentiation, we have overexpressed gp140* & in the NGF-responsive PC12 cell …
induced differentiation, we have overexpressed gp140* & in the NGF-responsive PC12 cell …
Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor
J Zhou, JS Valletta, ML Grimes… - Journal of …, 1995 - Wiley Online Library
TrkA is a receptor tyrosine kinase for nerve growth factor (NGF). Recent studies indicate that
NGF regulates not only activation of trkA kinase but also expression of the trkA gene. To …
NGF regulates not only activation of trkA kinase but also expression of the trkA gene. To …
Neurotrophin signal transduction by the Trk receptor
DR Kaplan, RM Stephens - Journal of neurobiology, 1994 - Wiley Online Library
The initial event in the neuronal differentiation of PC12 cells is the binding of the
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …
Transfection of TRK-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor.
E Lavenius, C Gestblom, I Johansson… - Cell growth & …, 1995 - europepmc.org
Human neuroblastoma cell lines frequently express the TRK-A proto-oncogene and bind
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …
An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.
DO Clary, LF Reichardt - Proceedings of the National …, 1994 - National Acad Sciences
TrkA, a member of the receptor tyrosine kinase family, binds nerve growth factor (NGF) and
subsequently activates intracellular signaling pathways. Previous studies have found …
subsequently activates intracellular signaling pathways. Previous studies have found …