Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a vesicular stomatitis virus-based vaccine

W Furuyama, K Shifflett, AN Pinski, AJ Griffin… - MBio, 2022 - Am Soc Microbiol
The ongoing pandemic of coronavirus (CoV) disease 2019 (COVID-19) continues to exert a
significant burden on health care systems worldwide. With limited treatments available …

[HTML][HTML] Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine

W Furuyama, K Shifflett, AN Pinski, AJ Griffin… - BioRxiv, 2021 - ncbi.nlm.nih.gov
The ongoing pandemic of Coronavirus disease 2019 (COVID-19) continues to exert a
significant burden on health care systems worldwide. With limited treatments available …

Optimization of single-dose VSV-based COVID-19 vaccination in hamsters

KL O'Donnell, CS Clancy, AJ Griffin, K Shifflett… - Frontiers in …, 2022 - frontiersin.org
The ongoing COVID-19 pandemic has resulted in global effects on human health, economic
stability, and social norms. The emergence of viral variants raises concerns about the …

Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera

AS Espeseth, M Yuan, M Citron, L Reiserova… - …, 2022 - thelancet.com
Background To investigate a vaccine technology with potential to protect against
coronavirus disease 2019 (COVID-19) and reduce transmission of severe acute respiratory …

Safety and immunogenicity of intramuscular, single-dose V590 (rVSV-SARS-CoV-2 Vaccine) in healthy adults: Results from a phase 1 randomised, double-blind …

JA Robbins, D Tait, Q Huang, S Dubey, T Crumley… - …, 2022 - thelancet.com
Background Vaccines against COVID-19 are needed to overcome challenges associated
with mitigating the global pandemic. We report the safety and immunogenicity of V590, a live …

VSV-based vaccines reduce virus shedding and viral load in hamsters infected with SARS-CoV-2 variants of concern

KL O'Donnell, T Gourdine, P Fletcher, K Shifflett… - Vaccines, 2022 - mdpi.com
The continued progression of the COVID-19 pandemic can partly be attributed to the ability
of SARS-CoV-2 to mutate and introduce new viral variants. Some of these variants with the …

A vesicular stomatitis virus-based prime-boost vaccination strategy induces potent and protective neutralizing antibodies against SARS-CoV-2

GN Kim, J Choi, K Wu, N Saeedian, E Yang… - PLoS …, 2021 - journals.plos.org
The development of safe and effective vaccines to prevent SARS-CoV-2 infections remains
an urgent priority worldwide. We have used a recombinant vesicular stomatitis virus (rVSV) …

Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from …

P Pérez, D Astorgano, G Albericio, S Flores… - Frontiers in …, 2022 - frontiersin.org
Current coronavirus disease-19 (COVID-19) vaccines are administered by the intramuscular
route, but this vaccine administration failed to prevent severe acute respiratory syndrome …

Characterization of immune response diversity in rodents vaccinated with a vesicular stomatitis virus vectored COVID-19 vaccine

S Wang, C Zhang, B Liang, W Wang, N Feng, Y Zhao… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the prime
challenge facing public health safety since 2019. Correspondingly, coronavirus disease …

[HTML][HTML] Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis in mice

JB Case, PW Rothlauf, RE Chen, NM Kafai, JM Fox… - Cell host & …, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
human infections, and an effective vaccine is critical to mitigate coronavirus-induced disease …