The fundamental physiology of circulating red blood cells (RBCs) and platelets involving
regulation of oxygen transport and hemostasis, respectively, are well-described in the …

Oxidative stress is involved in the chronic pathological vascular remodelling of both
abdominal aortic aneurysm and occlusive atherosclerosis. Red blood cells (RBCs) …

Significance: An imbalance between the production and the detoxification of reactive oxygen
species and reactive nitrogen species (ROS/RNS) can be implicated in many pathological …

The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …

Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …

Increased oxidative stress appears to be of fundamental importance in the pathogenesis
and development of several disease processes. Indeed, it is well known that reactive oxygen …

Nitric oxide (NO) is widely accepted as a central regulator of vascular tone and a vast array
of other cardiovascular signaling mechanisms. An emerging player in these mechanisms is …

Red blood cells may exert both an antioxidant and a prooxidant activity. The first is exerted
in physiologic conditions, whereas the second can be detected in several human …

There is an increasing recognition of the role of red blood cells (RBCs) in cell signaling
above and beyond its oxygen (O2)-carrying function. A recent forum published in the …

Oxidative stress represents excessive intracellular levels of reactive oxygen species (ROS),
which plays a major role in the pathogenesis of cardiovascular disease. Besides having a …