Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors

X Gu, S Wang, W Zhang, C Li, L Guo, Z Wang, H Li… - …, 2023 - thelancet.com
Background As a debilitating condition that can impact a whole spectrum of people and
involve multi-organ systems, long COVID has aroused the most attention than ever …

Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning

MA Patel, MJ Knauer, M Nicholson, M Daley… - Molecular …, 2023 - Springer
Background Survivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-
infection, referred to as “Long-COVID”. A lack of Long-COVID biomarkers and …

Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19

M Zoodsma, AH de Nooijer, I Grondman… - Frontiers in …, 2022 - frontiersin.org
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the highly
infectious Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). There is an …

Longitudinal proteomic profiling provides insights into host response and proteome dynamics in COVID‐19 progression

JS Lee, D Han, SY Kim, KH Hong, M Jang, MJ Kim… - …, 2021 - Wiley Online Library
In managing patients with coronavirus disease 2019 (COVID‐19), early identification of
those at high risk and real‐time monitoring of disease progression to severe COVID‐19 is a …

Plasma proteomics identify biomarkers and pathogenesis of COVID-19

T Shu, W Ning, D Wu, J Xu, Q Han, M Huang, X Zou… - Immunity, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic is a global public health
crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Here …

Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection

G Captur, JC Moon, CC Topriceanu, G Joy… - …, 2022 - thelancet.com
Background The majority of those infected by ancestral Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require …

A time-resolved proteomic and prognostic map of COVID-19

V Demichev, P Tober-Lau, O Lemke, T Nazarenko… - Cell systems, 2021 - cell.com
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection
to severe organ damage and death. We characterized the time-dependent progression of …

Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

MAY Al-Nesf, HB Abdesselem, I Bensmail… - Nature …, 2022 - nature.com
COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …

High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion

PE Geyer, FM Arend, S Doll, ML Louiset… - EMBO molecular …, 2021 - embopress.org
A deeper understanding of COVID‐19 on human molecular pathophysiology is urgently
needed as a foundation for the discovery of new biomarkers and therapeutic targets. Here …

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

MR Filbin, A Mehta, AM Schneider, KR Kays… - Cell Reports …, 2021 - cell.com
Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …