Inflammation plays a critical role in conditions such as acute liver failure, acute-on-chronic
liver failure, and ischemia–reperfusion-induced liver injury. Various pathogenic pathways …

Mesenchymal stem cells (MSCs), as the most common cell source for stem cell therapy, play
an important role in the modulation of innate and adaptive immune responses and have …

Liver disease is a leading cause of mortality and morbidity that is rising globally. Liver
dysfunctions are classified into acute and chronic diseases. Various insults, including viral …

Background: Although increasing preclinical studies have emphasized the benefits of
exosome-related therapies, the efficacy of mesenchymal stromal cell (MSC)-derived …

Liver injury is a serious condition which may often lead to hepatic failure. It can occur as a
consequence of insults and toxicity related to viral hepatitis, drugs, ischemia, alcohol, drugs …

Sepsis-associated liver dysfunction (SALD) aggravates the disease progression and
prognosis of patients. Macrophages in the liver play a crucial role in the occurrence and …

Liver failure includes distinct subgroups of diseases: Acute liver failure (ALF) without
preexisting cirrhosis, acute-on-chronic liver failure (ACLF)(severe form of cirrhosis …

Mesenchymal stem cell small extracellular vesicles (MSC-sEVs) are a priority for
researchers because of their role in tissue regeneration. sEVs act as paracrine factors and …

Liver dysfunctions are classified into acute and chronic diseases, which comprise a
heterogeneous group of pathological features and a high mortality rate. Liver transplantation …

Therapeutic effects of Mesenchymal Stem/Stromal Cells (MSCs) transplantation have been
observed in various disease models. However, it is thought that MSCs-mediated effects …