Post-translational modifications of proteins have emerged as a major mechanism for
regulating gene expression. However, our understanding of how histone modifications …

Histone modifications are key regulators of chromatin function. However, little is known to
what extent histone modifications can directly impact on chromatin. Here, we address how a …

Linker histone H1 has a key role in maintaining higher order chromatin structure and
genome stability, but how H1 functions in these processes is elusive. Here, we report that …

Promoter chromatin disassembly is a widely used mechanism to regulate eukaryotic
transcriptional induction. Delaying histone H3/H4 removal from the yeast PHO5 promoter …

The impact of histone acetylation on transcription was revealed over 50 years ago by Allfrey
and colleagues. However, it took decades for an understanding of the fine mechanism by …

Histone posttranslational modifications and chromatin dynamics are inextricably linked to
eukaryotic gene expression. Among the many modifications that have been characterized …

DNA in eukaryotic organisms does not exist free in cells, but instead is present as chromatin,
a complex assembly of DNA, histone proteins, and chromatin-associated proteins …

Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved
hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) …

Post-translational histone modifications and linker histone incorporation regulate chromatin
structure and genome activity. How these systems interface on a molecular level is unclear …

Histone lysine acetylation is a major mechanism by which cells regulate the structure and
function of chromatin, and new sites of acetylation continue to be discovered. Here we …