Background Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …

BACKGROUND: Apelin is an endogenous ligand for the G-protein-coupled 7-
transmembrane receptor, APJ. The administration of apelin-13, a truncated 13-amino acid …

Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a
potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …

Studies have shown significant cardiovascular effects of exogenous apelin administration,
including the potent activation of cardiac contraction. However, the role of the endogenous …

Aims: Apelin and its receptor have emerged as promising targets for the treatment of insulin
resistance. Indeed, peripheral administration of apelin stimulates glucose utilization and …

Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling
protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans …

Background: It has been suggested that the metabolic benefits of physical exercise could be
mediated by myokines. We examined here the effect of exercise training on skeletal muscle …

The adipocytokine apelin and its G protein-coupled APJ receptor were initially isolated from
a bovine stomach and have been detected in the brain and cardiovascular system. Recent …

Aims Apelin is a recently identified adipokine known to improve glucose tolerance and
insulin sensitivity in murine models. This study was dedicated to the proof of concept that …

The apelinergic system is a mammalian peptide hormone network with key physiological
roles. Apelin isoforms and analogues are believed to be promising therapeutics for …