A wide range of adipokines identified over the past years has allowed considering the white
adipose tissue as a secretory organ closely integrated into overall physiological and …

Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor
(APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions …

The apelin/apelin receptor system is widely distributed and has a dominant role in
cardiovascular homeostasis and disease. The apelin gene is X-linked and is synthesized as …

Apelin has been recognized as an adipokine that plays an important role in regulating
energy metabolism and is credited with antiobesity and antidiabetic properties. This study …

Apelin, the endogenous ligand of the G protein-coupled APJ receptor, is a peptide mediator
with emerging regulatory actions in the heart. The aim of the present studies was to explore …

Aims Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key
event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an …

The G protein-coupled receptor APJ and its cognate ligand, apelin, are widely expressed
throughout human body. They are implicated in different key physiological processes such …

J. Neurochem.(2011) 118, 1113–1123. Abstract Excitotoxic neuronal damage via over‐
activation of the NMDA receptor has been implicated in many neurodegenerative diseases …

Apelin was initially isolated from bovine stomach and is an endogenous neuropeptide. It is a
native ligand of the apelin receptor (APJ). Some research has found that apelin peptides …

Apelin is a peptide present in different cell types and secreted by adipocytes in humans and
rodents. Apelin exerts its effects through a G-protein-coupled receptor called APJ. During the …