Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking

L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan… - Immunity, 2023 - cell.com
SARS-CoV-2 continues to evolve, with many variants evading clinically authorized
antibodies. To isolate monoclonal antibodies (mAbs) with broadly neutralizing capacities …

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern threatens the efficacy of existing vaccines and therapeutic antibodies and …

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

W Li, Y Chen, J Prévost, I Ullah, M Lu, SY Gong… - Cell reports, 2022 - cell.com
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
Prevention of viral escape and increased coverage against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal …

Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike

S Changrob, Y Fu, JJ Guthmiller, PJ Halfmann, L Li… - Mbio, 2021 - Am Soc Microbiol
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …

A combination of receptor-binding domain and N-terminal domain neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

D Haslwanter, ME Dieterle, AZ Wec, CM O'brien… - Mbio, 2021 - Am Soc Microbiol
Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain …

[HTML][HTML] Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

AJ Greaney, AN Loes, KHD Crawford, TN Starr… - Cell host & …, 2021 - cell.com
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-
mediated immunity. To facilitate prospective surveillance for such evolution, we map how …

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

H Xiong, H Sun, S Wang, L Yuan… - Proceedings of the …, 2022 - National Acad Sciences
Antibody therapeutics for the treatment of COVID-19 have been highly successful. However,
the recent emergence of the Omicron variant has posed a challenge, as it evades detection …

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

AJ Greaney, TN Starr, RT Eguia, AN Loes… - PLoS …, 2022 - journals.plos.org
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it
is unknown if antibodies elicited by infection with these variants target the same or different …