Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages
that are more transmissible and resistant to currently approved antibody therapies poses a …
that are more transmissible and resistant to currently approved antibody therapies poses a …
SARS‐CoV‐2 neutralising antibody therapies: Recent advances and future challenges
The COVID‐19 pandemic represents an unparalleled global public health crisis. Despite
concerted research endeavours, the repertoire of effective treatment options remains limited …
concerted research endeavours, the repertoire of effective treatment options remains limited …
Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection
J Guenthoer, M Lilly, TN Starr… - Proceedings of the …, 2023 - National Acad Sciences
The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
Antibodies targeting the spike protein of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) present a promising approach to combat the coronavirus disease 2019 …
(SARS-CoV-2) present a promising approach to combat the coronavirus disease 2019 …
Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
A structural landscape of neutralizing antibodies against SARS-CoV-2 receptor binding domain
SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has
been spreading rampantly. The global scientific community has responded rapidly to …
been spreading rampantly. The global scientific community has responded rapidly to …
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal …
respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal …
Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2
X Rao, R Zhao, Z Tong, S Guo… - Proceedings of the …, 2023 - National Acad Sciences
Currently, monoclonal antibodies (MAbs) targeting the SARS-CoV-2 receptor binding
domain (RBD) of spike (S) protein are classified into seven classes based on their binding …
domain (RBD) of spike (S) protein are classified into seven classes based on their binding …
Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants
M Korenkov, M Zehner, H Cohen-Dvashi… - Immunity, 2023 - cell.com
Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies
Neutralizing monoclonal antibodies (nAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against …
coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against …