Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

WS Lee, AK Wheatley, SJ Kent, BJ DeKosky - Nature microbiology, 2020 - nature.com
Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) are being expedited through preclinical and clinical development. Data …

The anti–SARS-CoV-2 monoclonal antibody bamlanivimab minimally affects the endogenous immune response to COVID-19 vaccination

RJ Benschop, JL Tuttle, L Zhang… - Science Translational …, 2022 - science.org
As the coronavirus disease 2019 (COVID-19) pandemic evolves and vaccine rollout
progresses, the availability and demand for monoclonal antibodies for the prevention and …

Examining protective effects of SARS-CoV-2 neutralizing antibodies after vaccination or monoclonal antibody administration

D Follmann, MP O'Brien, J Fintzi, MP Fay… - Nature …, 2023 - nature.com
While new vaccines for SARS-CoV-2 are authorized based on neutralizing antibody (nAb)
titer against emerging variants of concern, an analogous pathway does not exist for …

Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?

L Lu, H Zhang, M Zhan, J Jiang, H Yin… - Science China Life …, 2020 - Springer
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
infected millions of people and caused tremendous morbidity and mortality worldwide …

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

BE Jones, PL Brown-Augsburger, KS Corbett… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed.
Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led …

Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma

FY Tso, SJ Lidenge, LK Poppe, PB Peña, SR Privatt… - PLoS …, 2021 - journals.plos.org
Background Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19
vaccine trials. However, nAb response against SARS-CoV-2, when present, decays rapidly …

[HTML][HTML] Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2

G Zhou, Q Zhao - International Journal of Biological Sciences, 2020 - ncbi.nlm.nih.gov
A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated
respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the …

High-resolution map of the Fc functions mediated by COVID-19-neutralizing antibodies

I Paciello, G Maccari, E Pantano… - Proceedings of the …, 2024 - National Acad Sciences
A growing body of evidence shows that fragment crystallizable (Fc)-dependent antibody
effector functions play an important role in protection from severe acute respiratory …

Human-IgG-neutralizing monoclonal antibodies block the SARS-CoV-2 infection

J Wan, S Xing, L Ding, Y Wang, C Gu, Y Wu, B Rong… - Cell reports, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) has become a worldwide threat to
humans, and neutralizing antibodies have therapeutic potential. We have purified more than …