SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients

M Olbei, I Hautefort, D Modos, A Treveil… - Frontiers in …, 2021 - frontiersin.org
Hyper-induction of pro-inflammatory cytokines, also known as a cytokine storm or cytokine
release syndrome (CRS), is one of the key aspects of the currently ongoing SARS-CoV-2 …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

Cytokine storm may not be the chief culprit for the deterioration of COVID-19

Y Gao, C Wang, K Kang, Y Peng, Y Luo, H Liu… - Viral …, 2021 - liebertpub.com
COVID-19 is spreading and ravaging all over the world, and the number of deaths is
increasing day by day without downward trend. However, there is limited knowledge of …

Storm at the time of corona: a glimpse at the current understanding and therapeutic opportunities of the SARS-CoV-2 cytokine storm

M Torabi-Rahvar, N Rezaei - Current Pharmaceutical Design, 2021 - ingentaconnect.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to severe
disease in some cases, leading to acute respiratory distress syndrome, multi-organ failure …

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …

IL‐6 at the center of cytokine storm: Circulating inflammation mediators as biomarkers in hospitalized COVID‐19 patients

HM Elbadawy, A Khattab, DS El‐Agamy… - Journal of Clinical …, 2023 - Wiley Online Library
Introduction The management of hospitalized COVID‐19 patients depends largely on
controlling the intensified inflammatory response known as the cytokine storm. Candidate …

[HTML][HTML] Laboratory biomarkers and prognosis in Covid‐19, where do we stand?

A Israni, CJ Goulden, A Harky - Reviews in medical virology, 2021 - ncbi.nlm.nih.gov
Coronavirus Disease 2019 (Covid‐19) has a wide range of clinical manifestations. Studies
have estimated that while 30%–60% of Covid‐19 cases are asymptomatic, up to 5% of …

COVID-19 severity shifts the cytokine milieu toward a proinflammatory state in Egyptian patients: a cross-sectional study

ML Salem, MM Eltoukhy, RE Shalaby… - Journal of Interferon & …, 2023 - liebertpub.com
Despite extensive research to decipher the immunological basis of coronavirus disease
(COVID-19), limited evidence on immunological correlates of COVID-19 severity from MENA …

Unraveling the mystery surrounding post-acute sequelae of COVID-19

RK Ramakrishnan, T Kashour, Q Hamid… - Frontiers in …, 2021 - frontiersin.org
More than one year since its emergence, corona virus disease 2019 (COVID-19) is still
looming large with a paucity of treatment options. To add to this burden, a sizeable subset of …

The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro …

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …