COVID-19 immunobiology: lessons learned, new questions arise

A Kaklamanos, K Belogiannis, P Skendros… - Frontiers in …, 2021 - frontiersin.org
There is strong evidence that COVID-19 pathophysiology is mainly driven by a
spatiotemporal immune deregulation. Both its phenotypic heterogeneity, spanning from …

Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications

R Hirawat, MA Saifi, C Godugu - Life sciences, 2021 - Elsevier
Such testing and trying time probably never seen before in the human history. The novel
coronavirus disease abbreviated as COVID-19 is the ongoing health crisis which entered …

Immune reactivity during COVID-19: Implications for treatment

C Napoli, G Benincasa, C Criscuolo, M Faenza… - Immunology letters, 2021 - Elsevier
Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to
acute respiratory distress syndrome (ARDS). The main hematological laboratory findings …

Immune signature of covid-19: In-depth reasons and consequences of the cytokine storm

P Niedźwiedzka-Rystwej, A Majchrzak… - International Journal of …, 2022 - mdpi.com
In the beginning of the third year of the fight against COVID-19, the virus remains at least still
one step ahead in the pandemic “war”. The key reasons are evolving lineages and …

Weathering the cytokine storm in COVID-19: therapeutic implications

G Iannaccone, R Scacciavillani, MG Del Buono… - Cardiorenal …, 2020 - karger.com
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently
emerged in Wuhan, Hubei-China, as responsible for the coronavirus disease 2019 (COVID …

[HTML][HTML] Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness

ED Morrell, PK Bhatraju, NA Sathe… - … of Physiology-Lung …, 2022 - journals.physiology.org
Critically ill patients manifest many of the same immune features seen in coronavirus
disease 2019 (COVID-19), including both “cytokine storm” and “immune suppression.” …

COVID 19: in the eye of the cytokine storm

G Liuzzo, C Patrono - 2021 - academic.oup.com
System in New York between 21 March and 28 April 2020. Serum levels of four inflammatory
cytokines were analysed upon admission with a rapid multiplex test: interleukin (IL)-6, IL-8 …

Immunological and inflammatory profiles in mild and severe cases of COVID-19

JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia… - Nature …, 2020 - nature.com
Abstract COVID-19 is associated with 5.1% mortality. Although the virological,
epidemiological, clinical, and management outcome features of COVID-19 patients have …

COVID-19: towards understanding of pathogenesis

W Cao, T Li - Cell research, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) is spreading rapidly. Although the
cause was quickly identified as a new coronavirus named SARS-CoV-2, our knowledge of …

Distinct cytokine profiles associated with COVID-19 severity and mortality

K Dorgham, P Quentric, M Gökkaya, S Marot… - Journal of Allergy and …, 2021 - Elsevier
Background Markedly elevated levels of proinflammatory cytokines and defective type-I
interferon responses were reported in patients with coronavirus disease 2019 (COVID-19) …