Bioinformatics analysis for circulating cell-free DNA in cancer

CC Huang, M Du, L Wang - Cancers, 2019 - mdpi.com
Molecular analysis of cell-free DNA (cfDNA) that circulates in plasma and other body fluids
represents a “liquid biopsy” approach for non-invasive cancer screening or monitoring. The …

Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients

DM Marzese, H Hirose, DSB Hoon - Expert review of molecular …, 2013 - Taylor & Francis
Qualitative and quantitative analysis of circulating cell-free DNA (cfDNA) is an emerging non-
invasive blood biomarker utilized to assess tumor progression and to evaluate prognosis …

Liquid biopsies beyond mutation calling: genomic and epigenomic features of cell-free DNA in cancer

AK Angeles, F Janke, S Bauer, P Christopoulos… - Cancers, 2021 - mdpi.com
Simple Summary Liquid biopsies provide a non-invasive means to diagnose and profile
tumors when tissue is not available. Sequence-based analysis of cell-free DNA (cfDNA) is …

Cell-free DNA (cfDNA): clinical significance and utility in cancer shaped by emerging technologies

S Volik, M Alcaide, RD Morin, C Collins - Molecular Cancer Research, 2016 - AACR
Precision oncology is predicated upon the ability to detect specific actionable genomic
alterations and to monitor their adaptive evolution during treatment to counter resistance …

Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

L Keller, Y Belloum, H Wikman, K Pantel - British journal of cancer, 2021 - nature.com
Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The
majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal …

New insights into structural features and optimal detection of circulating tumor DNA determined by single-strand DNA analysis

C Sanchez, MW Snyder, R Tanos, J Shendure… - NPJ genomic …, 2018 - nature.com
Circulating cell-free DNA (cfDNA) has received increasing interest as an apparent
breakthrough approach in diagnostics, personalized medicine, and tumor biology. However …

Cell-free DNA as a diagnostic marker for cancer: current insights

S Salvi, G Gurioli, U De Giorgi, V Conteduca… - Oncotargets and …, 2016 - Taylor & Francis
The increasing knowledge of the molecular pathogenesis of cancer and the rapid
development of new molecular techniques are promoting the study of early molecular …

A field guide for cancer diagnostics using cell‐free DNA: from principles to practice and clinical applications

AL Volckmar, H Sültmann, A Riediger… - Genes …, 2018 - Wiley Online Library
Recently, many genome‐wide profiling studies provided insights into the molecular make‐
up of major cancer types. The deeper understanding of these genetic alterations and their …

Size distribution of cell-free DNA in oncology

S Udomruk, S Orrapin, D Pruksakorn… - Critical reviews in …, 2021 - Elsevier
Tumor-specific, circulating cell-free DNA (cfDNA) in liquid biopsy test is a novel promising
biomarker in the advancement of cancer management, including early diagnosis, screening …

Epigenetic biomarkers in cell-free DNA and applications in liquid biopsy

W Gai, K Sun - Genes, 2019 - mdpi.com
Cell-free circulating DNA (cfDNA) in plasma has gained global interest as a diagnostic
material for noninvasive prenatal testing and cancer diagnosis, or the so-called “liquid …