Dynamic evolution of antimicrobial peptides underscores trade-offs between immunity and ecological fitness

MA Hanson, B Lemaitre, RL Unckless - Frontiers in Immunology, 2019 - frontiersin.org
There is a developing interest in how immune genes may function in other physiological
roles, and how traditionally non-immune peptides may, in fact, be active in immune contexts …

Perspectives on the evolutionary ecology of arthropod antimicrobial peptides

J Rolff, P Schmid-Hempel - Philosophical Transactions of …, 2016 - royalsocietypublishing.org
Antimicrobial peptides (AMPs) are important elements of the innate immune defence in
multicellular organisms that target and kill microbes. Here, we reflect on the various points …

The potential for adaptive maintenance of diversity in insect antimicrobial peptides

RL Unckless, BP Lazzaro - Philosophical Transactions of …, 2016 - royalsocietypublishing.org
Genes involved in immune defence are among the fastest evolving in the genomes of many
species. Interestingly, however, genes encoding antimicrobial peptides (AMPs) have shown …

Evolution of defence cocktails: Antimicrobial peptide combinations reduce mortality and persistent infection

C Zanchi, PR Johnston, J Rolff - Molecular Ecology, 2017 - Wiley Online Library
The simultaneous expression of costly immune effectors such as multiple antimicrobial
peptides is a hallmark of innate immunity of multicellular organisms, yet the adaptive …

The unique antimicrobial peptide repertoire of stick insects

M Shelomi, C Jacobs, A Vilcinskas, H Vogel - … & Comparative Immunology, 2020 - Elsevier
The comparative analysis of innate immunity across different insect taxa has revealed
unanticipated evolutionary plasticity, providing intriguing examples of immunity-related …

Evolutionary plasticity of insect immunity

A Vilcinskas - Journal of insect physiology, 2013 - Elsevier
Many insect genomes have been sequenced and the innate immune responses of several
species have been studied by transcriptomics, inviting the comparative analysis of immunity …

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

MA Hanson, L Grollmus, B Lemaitre - Science, 2023 - science.org
Antimicrobial peptides are host-encoded immune effectors that combat pathogens and
shape the microbiome in plants and animals. However, little is known about how the host …

Ageing leads to reduced specificity of antimicrobial peptide responses in Drosophila melanogaster

B Shit, A Prakash, S Sarkar… - Proceedings of the …, 2022 - royalsocietypublishing.org
Evolutionary theory predicts a late-life decline in the force of natural selection, possibly
leading to late-life deregulations of the immune system. A potential outcome of such …

Antimicrobial peptides: Application informed by evolution

BP Lazzaro, M Zasloff, J Rolff - Science, 2020 - science.org
BACKGROUND Antimicrobial peptides (AMPs) are small proteins with potent antibacterial,
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …

Immune genes and divergent antimicrobial peptides in flies of the subgenus Drosophila

MA Hanson, PT Hamilton, SJ Perlman - BMC evolutionary biology, 2016 - Springer
Background Drosophila is an important model for studying the evolution of animal immunity,
due to the powerful genetic tools developed for D. melanogaster. However, Drosophila is an …