Inflammation and antiviral immune response associated with severe progression of COVID-19

Q Zhang, Y Meng, K Wang, X Zhang, W Chen… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease-2019 (COVID-19) is a novel respiratory disease induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …

Transcriptomic signature differences between SARS-CoV-2 and influenza virus infected patients

S Bibert, N Guex, J Lourenco, T Brahier… - Frontiers in …, 2021 - frontiersin.org
The reason why most individuals with COVID-19 have relatively limited symptoms while
other develop respiratory distress with life-threatening complications remains unknown …

Dynamic blood single-cell immune responses in patients with COVID-19

L Huang, Y Shi, B Gong, L Jiang, Z Zhang… - Signal transduction and …, 2021 - nature.com
Abstract The 2019 coronavirus disease (COVID-19) outbreak caused by the SARS-CoV-2
virus is an ongoing global health emergency. However, the virus' pathogenesis remains …

[HTML][HTML] Differentially expressed immune response genes in COVID-19 patients based on disease severity

S Li, X Duan, Y Li, M Li, Y Gao, T Li, S Li, L Tan… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: Dysregulated immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) are thought to underlie the progression of coronavirus disease …

[HTML][HTML] Heightened circulating interferon-inducible chemokines, and activated pro-cytolytic Th1-cell phenotype features Covid-19 aggravation in the second week of …

C Tincati, ES Cannizzo, M Giacomelli… - Frontiers in …, 2020 - frontiersin.org
Covid-19 features a delayed onset of critical illness occurring approximately one week from
the beginning of symptoms, which corresponds to the bridging of innate and adaptive …

Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19

HY Zheng, M Xu, CX Yang, RR Tian, M Zhang… - Signal transduction and …, 2020 - nature.com
Understanding the processes of immune regulation in patients infected with the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment …

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

PA Mudd, JC Crawford, JS Turner, A Souquette… - Science …, 2020 - science.org
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and
influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited …

Longitudinal peripheral blood transcriptional analysis reveals molecular signatures of disease progression in COVID-19 patients

Q Yan, P Li, X Ye, X Huang, B Feng, T Ji… - The journal of …, 2021 - journals.aai.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus named
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some patients …

Dysregulation of the immune response in coronavirus disease 2019

L Mohamed Khosroshahi, N Rezaei - Cell Biology International, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can trigger a cytokine
storm in the pulmonary tissue by releasing various types of mediators, leading to acute …

Single-cell transcriptome analysis highlights a role for neutrophils and inflammatory macrophages in the pathogenesis of severe COVID-19

H Shaath, R Vishnubalaji, E Elkord, NM Alajez - Cells, 2020 - mdpi.com
Cumulative data link cytokine storms with coronavirus disease 2019 (COVID-19) severity.
The precise identification of immune cell subsets in bronchoalveolar lavage (BAL) and their …