Introduction Toll-like receptors 7 and 8 (TLR7 and TLR8) are endosomal immune receptors
that initiate an innate immune response and can facilitate activation of the adaptive immune …

Toll-like receptors (TLRs) 7 and 8 play an important role in the activation of innate immune
cells in mammals. These evolutionarily conserved receptors serve as important sentinels in …

Introduction: Toll-like receptor (TLR) 7 and TLR8 are functionally localized to endosomes
and recognize specific RNA sequences. They play crucial roles in initiating innate and …

The toll-like receptor (TLR) family is an evolutionarily conserved component of the innate
immune system, responsible for the early detection of foreign or endogenous threat signals …

Toll-like receptor 7 (TLR7) is a class of pattern recognition receptors (PRRs) recognizing the
pathogen-associated elements and damage and as such is a major player in the innate …

Small molecule toll-like receptor (TLR) 7 agonists have gathered considerable interest as
promising therapeutic agents for applications in cancer immunotherapy. Herein, we describe …

The toll-like receptors (TLRs) play key roles in activation of the innate immune system.
Aberrant activation of TLR7 and TLR8 pathways can occur in the context of autoimmune …

Several toll-like receptors (TLRs) reside inside endosomes of specific immune cells—among
them, aberrant activation of TLR7 and TLR9 is implicated in myriad contexts of autoimmune …

TLR9 is one of the major innate immune receptors expressed in the endosomes of pDCs
and B cells in humans. Aberrant TLR9 activation is implicated in several autoimmune and …

Toll-like receptors (TLRs) are components of innate immunity that play a crucial role in
several diseases, including chronic inflammatory and infectious diseases, autoimmune …