Polymer-based eye drops are the most used drug delivery system to treat dry eye disease
(DED). Therefore, the mucoadhesion between the polymer and the ocular mucin is crucial to …

Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye
drops because they associate the advantages of solutions such as accuracy and …

From the past few decades, tremendous awareness has been laid on the use of natural
polymers in ocular drug delivery. Chitosan, a modified natural carbohydrate polymer, has …

Objective: Intraocular pressure has always been a great challenge for topical ophthalmic
drugs. The study aimed to develop ocular surfactant based nanovesicles (NVs) carried in …

In the present update on mucoadhesive ocular dosage forms, the tremendous advances in
the biochemistry of mucins, the development of new polymers, the use of drug complexes …

The aim of this investigation was to develop 5-fluorouracil (5-FU) loaded chitosan
nanoparticles (CH-DNPs) for ophthalmic delivery. CH-DNPs were fabricated by ionotropic …

Importance of the field: A major challenge emanating in the design of topical ophthalmic
preparations is their short precorneal residence time. Retention of a drug delivery system in …

Topical ocular conditions such as cornea transplant rejection and keratoconjunctivitis sicca
(so called dry eye disease) require therapeutic concentration of immunosuppressant onto …

This study was to develop a thiolated non-ionic surfactant, cysteine-polyethylene glycol
stearate (Cys-PEG-SA), for the assembling of nanoparticulate ocular drug delivery system …

Cholesterol hydrophobically modified chitosan (CS-CH) containing 1.7–4.7 cholesterol
groups per 100 anhydroglucosamine units of chitosan were synthesized by an EDC …