Chitosan derivatives as effective nanocarriers for ocular release of timolol drug

PI Siafaka, A Titopoulou, EN Koukaras… - International journal of …, 2015 - Elsevier
The aim of the present study was to evaluate the effectiveness of neat chitosan (CS) and its
derivatives with succinic anhydride (CSUC) and 2-carboxybenzaldehyde (CBCS) as …

PLGA microparticles entrapping chitosan-based nanoparticles for the ocular delivery of ranibizumab

N Elsaid, TL Jackson, Z Elsaid… - Molecular …, 2016 - ACS Publications
Age-related macular degeneration (AMD) is the leading cause of certified vision loss
worldwide. The standard treatment for neovascular AMD involves repeated intravitreal …

Alginate nanoparticles as ocular drug delivery carriers

S Kianersi, A Solouk, S Saber-Samandari… - Journal of Drug Delivery …, 2021 - Elsevier
The eye is the most susceptible organ of the body by assigning 30% of the brain cells and is
exposed to various environmental damage due to contact with the outside environment. In …

Development, Optimization, and In Vitro/In Vivo Characterization of Enhanced Lipid Nanoparticles for Ocular Delivery of Ofloxacin: the Influence of Pegylation and …

HM Eid, MH Elkomy, SF El Menshawe, HF Salem - AAPS pharmscitech, 2019 - Springer
This study aims to investigate whether modification of solid lipid nanoparticles (SLNs) with
chitosan (CTS) and polyethylene glycol (PEG) coatings enhances corneal retention time and …

New nanoparticles for topical ocular delivery of erythropoietin

B Silva, J Marto, B São Braz, E Delgado… - International Journal of …, 2020 - Elsevier
Erythropoietin (EPO) is known for its neuroprotective and neuroregenerative properties. EPO
topical ocular administration has not been tested yet and its bioavailability could be …

Stimulus responsive ocular gentamycin-ferrying chitosan nanoparticles hydrogel: formulation optimization, ocular safety and antibacterial assessment

NK Alruwaili, A Zafar, SS Imam, KS Alharbi… - International Journal …, 2020 - Taylor & Francis
Purpose The present study was designed to study the gentamycin (GTM)-loaded stimulus-
responsive chitosan nanoparticles to treat bacterial conjunctivitis. Methods GTM-loaded …

Natural bioadhesive biodegradable nanoparticle-based topical ophthalmic formulations for management of glaucoma

MM Ibrahim, AEH Abd-Elgawad… - … vision science & …, 2015 - tvst.arvojournals.org
Purpose:: We prepared and characterized topical ophthalmic formulations containing
brimonidine-loaded bioadhesive cationic chitosan or anionic alginate nanoparticles (NPs) …

Novel chitosan-coated niosomal formulation for improved management of bacterial conjunctivitis: a highly permeable and efficient ocular nanocarrier for azithromycin

HM Eid, IA Naguib, RI Alsantali, I Alsalahat… - Journal of …, 2021 - Elsevier
In the present study, we aimed to formulate, optimize, and characterize azithromycin
chitosan coated niosomes (AZM-CTS-NSM) as a novel colloidal system that increases …

A comparative study on the efficiency of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan surface modified nanostructured lipid carrier …

J Li, D Liu, G Tan, Z Zhao, X Yang, W Pan - Carbohydrate polymers, 2016 - Elsevier
To develop a potential nanocarrier for the topical ocular administration of curcumin (CUR), a
novel thiolated chitosan was synthesized by the covalent binding between N-acetyl-l …

Resveratrol encapsulation in high molecular weight chitosan-based nanogels for applications in ocular treatments: Impact on human ARPE-19 culture cells

FS Buosi, A Alaimo, MC Di Santo, F Elias… - International Journal of …, 2020 - Elsevier
Oxidative stress and inflammation play a pivotal role in ocular diseases. Resveratrol (RSV)
is a natural bioactive that has recently attracted attention due to it potent antioxidant and anti …