T-cell-mediated immune responses play indispensable roles in the defense against
infectious pathogens including human immunodeficiency virus type 1 (HIV-1) which can …

T cells are functionally compromised during HIV infection despite their increased activation
and proliferation. Although T cell hyperactivation is one of the best predictive markers for …

Each time the virus starts a new round of expression/replication, even under effective
antiretroviral therapy (ART), the transactivator of viral transcription Tat is one of the first HIV-1 …

The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat
role as activator of HIV-1 transcription, it exerts several important functions on infected and …

Objective: HIV infection is characterized by several immune dysfunctions, such as chronic
activation of the immune system, premature aging and loss of CD4+ T cells, in particular …

HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its
role as the transactivator of HIV transcription is well established, other roles associated with …

HIV is the primary etiological agent of AIDS. Effective treatment and prevention of HIV
remain a top priority for governments and international health authorities worldwide …

Tat is an early regulatory protein that plays a major role in human HIV-1 replication and
AIDS pathogenesis, and therefore, it represents a key target for the host immune response …

Abstract HIV-1 Tat, an 86 amino acid protein of HIV-1, is required for efficient viral replication
and viral gene expression. Tat activates a variety of host factors, some of which play a critical …

Objective: HIV infection is characterized by several immune dysfunctions of both CD8+ and
CD4+ T cells as hyperactivation, impairment of functionality and expansion of memory T …