Genetics of venous thrombosis: insights from a new genome wide association study

M Germain, N Saut, N Greliche, C Dina, JC Lambert… - PloS one, 2011 - journals.plos.org
Background Venous Thrombosis (VT) is a common multifactorial disease associated with a
major public health burden. Genetics factors are known to contribute to the susceptibility of …

Genetics of venous thrombosis: update in 2015

PE Morange, P Suchon… - Thrombosis and …, 2015 - thieme-connect.com
Venous thrombosis (VT) is a common multifactorial disease with a genetic component that
was first suspected nearly 60 years ago. In this review, we document the genetic …

Current knowledge on the genetics of incident venous thrombosis

PE Morange, DA Trégouët - Journal of thrombosis and …, 2013 - Wiley Online Library
The genetic burden underlying venous thrombosis (VT) is characterized by a sibling relative
risk of 2.5 and a strong heritability whose estimates varied from 35% to 60% according to …

A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24. 1

PE Morange, I Bezemer, N Saut, L Bare… - The American Journal of …, 2010 - cell.com
To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT),
we conducted a multistage study, following results of a previously published GWAS that …

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

M Germain, DI Chasman, H De Haan, W Tang… - The American Journal of …, 2015 - cell.com
Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …

Epidemiology and genetics of venous thromboembolism and chronic venous disease

RA Baylis, NL Smith, D Klarin, E Fukaya - Circulation research, 2021 - Am Heart Assoc
Venous disease is a term that broadly covers both venous thromboembolic disease and
chronic venous disease. The basic pathophysiology of venous thromboembolism and …

Cross-ancestry investigation of venous thromboembolism genomic predictors

F Thibord, D Klarin, JA Brody, MH Chen, MG Levin… - Circulation, 2022 - Am Heart Assoc
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …

Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

S Lindström, LU Wang, EN Smith… - Blood, The Journal …, 2019 - ashpublications.org
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

[HTML][HTML] A genome‐wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24. 2 and 9q

JA Heit, SM Armasu, YW Asmann… - Journal of thrombosis …, 2012 - Elsevier
Objectives: To identify venous thromboembolism (VTE) disease‐susceptibility genes.
Patients and methods: We performed in silico genome wide association scan (GWAS) …

A genome‐wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium

W Tang, M Teichert, DI Chasman, JA Heit… - Genetic …, 2013 - Wiley Online Library
Venous thromboembolism (VTE) is a common, heritable disease resulting in high rates of
hospitalization and mortality. Yet few associations between VTE and genetic variants, all in …