Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive
tumorigenesis. However, the origin of intratumoural functional heterogeneity between …

Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …

Recent longitudinal studies of glioblastoma (GBM) have demonstrated a lack of apparent
selection pressure for specific DNA mutations in recurrent disease. Single-cell lineage …

Glioblastoma multiforme is the most common primary malignant brain tumour, with a median
survival of about one year. This poor prognosis is due to therapeutic resistance and tumour …

Neural–tumor interactions drive glioma growth as evidenced in preclinical models, but
clinical validation is limited. We present an epigenetically defined neural signature of …

To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor
therapy response, we performed DNA and RNA sequencing on GBM samples and the …

The inference of transcriptional networks that regulate transitions into physiological or
pathological cellular states remains a central challenge in systems biology. A mesenchymal …

Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis.
Here, we demonstrate that these histological features are associated with distinct …

The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear,. Here we analysed temporally separated DNA-sequencing …

Cancers arise through a process of somatic evolution that can result in substantial sub-
clonal heterogeneity within tumours. The mechanisms responsible for the coexistence of …