Physical contact between mesenchymal stem cells and endothelial precursors induces distinct signatures with relevance to the very early phase of regeneration

B Hafen, S Wiesner, K Schlegelmilch… - Journal of Cellular …, 2018 - Wiley Online Library
Multipotent adult stem cells/precursor cells, especially of the mesenchymal and endothelial
lineage, may have great potential for bone tissue engineering. Although their potential is …

Human Endothelial‐Like Differentiated Precursor Cells Maintain Their Endothelial Characteristics When Cocultured with Mesenchymal Stem Cell and Seeded onto …

D Henrich, K Wilhelm, J Warzecha… - Mediators of …, 2013 - Wiley Online Library
Introduction. Cancellous bone is frequently used for filling bone defects in a clinical setting. It
provides favourable conditions for regenerative cells such as MSC and early EPC. The …

Increased extracellular matrix and proangiogenic factor transcription in endothelial cells after cocultivation with primary human osteoblasts

F Simunovic, D Steiner, D Pfeifer… - Journal of Cellular …, 2013 - Wiley Online Library
The most promising strategies in bone engineering have concentrated on providing
sufficient vascularization to support the newly forming tissue. In this context, recent research …

Whatever their differentiation status, human progenitor derived–or mature–endothelial cells induce osteoblastic differentiation of bone marrow stromal cells

NB Thébaud, R Siadous, R Bareille… - Journal of tissue …, 2012 - Wiley Online Library
Association of the bone‐forming osteoblasts (OBs) and vascular endothelial cells (ECs) into
a biomaterial composite provides a live bone graft substitute that can repair the bone defect …

Human endothelial and foetal femur-derived stem cell co-cultures modulate osteogenesis and angiogenesis

S Inglis, D Christensen, DI Wilson, JM Kanczler… - Stem cell research & …, 2016 - Springer
Background A dynamic vasculature is a prerequisite for bone formation where the
interaction of bone cells and endothelial cells is essential for both the development and the …

[PDF][PDF] Early endothelial progenitor cells as a source of myeloid cells to improve the pre-vascularisation of bone constructs

Y Shi, G Kramer, A Schröder, CJ Kirkpatrick… - Eur Cell …, 2014 - ecmjournal.org
According to present knowledge, blood derived endothelial progenitor cells (EPC) might act
as proangiogenic myeloid cells, which play a fundamental role in the regulation of …

The role of endothelial progenitor cells in prevascularized bone tissue engineering: development of heterogeneous constructs

NE Fedorovich, RT Haverslag, WJA Dhert… - … Engineering Part A, 2010 - liebertpub.com
In vitro prevascularization of bone grafts with endothelial progenitor cells (EPCs) is a
promising strategy to improveimplant survival. In this study we show bone formation in …

In vitro model of vascularized bone: synergizing vascular development and osteogenesis

C Correia, WL Grayson, M Park, D Hutton, B Zhou… - PloS one, 2011 - journals.plos.org
Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

Co-culture with endothelial progenitor cells promotes survival, migration, and differentiation of osteoclast precursors

H Pang, XH Wu, SL Fu, F Luo, ZH Zhang… - Biochemical and …, 2013 - Elsevier
In this study, we report the effect of endothelial progenitor cells (EPCs) on the biological
behavior of osteoclast precursors in vitro by establishing an indirect co-culture system of …

Endothelial cells promote osteogenesis by establishing a functional and metabolic coupling with human mesenchymal stem cells

S Petrillo, T Genova, G Chinigò, I Roato… - Frontiers in …, 2022 - frontiersin.org
Bone formation involves a complex crosstalk between endothelial cells (EC) and
osteodifferentiating stem cells. This functional interplay is greatly mediated by the paracrine …