Neurotrophin‐mediated cell survival and differentiation of vertebrate neurons is caused by
ligand‐specific binding to the Trk family of tyrosine kinase receptors. However, sites in the …

The neurotrophins represent a family of survival and differentiation factors that exert
profound effects in the central and peripheral nervous systems (1). Five neurotrophins, NGF …

The study of structure–function relationships in the neurotrophin family has in recent years
increased our understanding of several important aspects of neurotrophin function. Site …

We have exploited a battery of approaches to address several controversies that have
accompanied the expansion of the nerve growth factor (NCF) family of neurotrophic factors …

Neurotrophins regulate differentiation and survival of vertebrate neurons through binding to
members of the Trk family of receptor tyrosine kinases and to a common low affinity receptor …

The neurotrophins influence survival and maintenance of vertebrate neurons in the
embryonic, early post‐natal and post‐developmental stages of the nervous system. Binding …

Revised Manuscript Received May 23, 1995® abstract: TrkB is a member of the Trk family of
neurotrophin receptors. Its extracellular domain exhibits the same modular structure found in …

The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors
that mediate the biological properties of the NGF family of neurotrophins. This family of …

Neurotrophic factors are important for survival and maintenance of neurons during
developmental and adult stages of the vertebrate nervous system. The neurotrophins …

The extracellular domains of the TrkA and TrkB neurotrophin receptors contain defined
structural modules such as immunoglobulin‐like domains and leucine‐rich motifs …