[HTML][HTML] Oral antivirals for the prevention and treatment of SARS-CoV-2 infection

V Soriano, C De-Mendoza, B Edagwa, A Treviño… - AIDS …, 2022 - ncbi.nlm.nih.gov
Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-
threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against …

Oral antiviral treatments for COVID-19: opportunities and challenges

L Rahmah, SO Abarikwu, AG Arero, M Essouma… - Pharmacological …, 2022 - Springer
The use of antiviral COVID-19 medications can successfully inhibit SARS-CoV-2 replication
and prevent disease progression to a more severe form. However, the timing of antiviral …

[HTML][HTML] First-generation oral antivirals against SARS-CoV-2

P Sendi, RR Razonable, SB Nelson, A Soriano… - Clinical Microbiology …, 2022 - Elsevier
Background Oral drugs against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) have received emergency use authorization for the treatment of mild-to-moderate …

The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses

EA Meyerowitz, Y Li - Clinical Infectious Diseases, 2024 - academic.oup.com
The goals of coronavirus disease 2019 (COVID-19) antiviral therapy early in the pandemic
were to prevent severe disease, hospitalization, and death. As these outcomes have …

Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

R Rosales, BL McGovern, ML Rodriguez, DK Rai… - BioRxiv, 2022 - biorxiv.org
Variants of SARS-CoV-2 have become a major public health concern due to increased
transmissibility, and escape from natural immunity, vaccine protection, and monoclonal …

Therapeutics for COVID-19

SS Toussi, JL Hammond, BS Gerstenberger… - Nature …, 2023 - nature.com
Vaccines and monoclonal antibody treatments to prevent severe coronavirus disease 2019
(COVID-19) illness were available within a year of the pandemic being declared but there …

The need for speed and efficiency: a brief review of small molecule antivirals for COVID-19

AC Puhl, TR Lane, F Urbina, S Ekins - Frontiers in Drug Discovery, 2022 - frontiersin.org
While we currently have multiple highly effective vaccines approved for use against SARS-
CoV-2 in the USA and other countries, there are far fewer small molecule antivirals …

Risk/benefit profiles of currently approved oral antivirals for treatment of COVID-19: similarities and differences

S Corritori, N Savchuk, CD Pauza - Covid, 2022 - mdpi.com
A complete response to the challenge of COVID-19 requires diagnosis, prevention, and
treatment strategies. Until recently, the treatment arm has included largely ineffective, often …

Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence

I Karniadakis, N Mazonakis, C Tsioutis… - Infectious Disease …, 2023 - mdpi.com
Vaccines remain the cornerstone of medical prevention and are highly effective in reducing
the risk of severe disease and death due to coronavirus disease 2019 (COVID-19). In the …

A guide to COVID‐19 antiviral therapeutics: a summary and perspective of the antiviral weapons against SARS‐CoV‐2 infection

DK Brady, AR Gurijala, L Huang, AA Hussain… - The FEBS …, 2024 - Wiley Online Library
Antiviral therapies are integral in the fight against SARS‐CoV‐2 (ie severe acute respiratory
syndrome coronavirus 2), the causative agent of COVID‐19. Antiviral therapeutics can be …