Tendon tissue engineering: Current progress towards an optimized tenogenic differentiation protocol for human stem cells

I Donderwinkel, RS Tuan, NR Cameron, JE Frith - Acta Biomaterialia, 2022 - Elsevier
Tendons are integral to our daily lives by allowing movement and locomotion but are
frequently injured, leading to patient discomfort and impaired mobility. Current clinical …

Tenogenic differentiation of stem cells for tendon repair—what is the current evidence?

PPY Lui, YF Rui, M Ni, KM Chan - Journal of tissue engineering …, 2011 - Wiley Online Library
Tendon/ligament injuries are very common in sports and other rigorous activities. Tendons
regenerate and repair slowly and inefficiently in vivo after injury. The limited ability of tendon …

[HTML][HTML] Current concepts on tenogenic differentiation and clinical applications

Y Liu, CW Suen, J Zhang, G Li - Journal of orthopaedic translation, 2017 - Elsevier
Tendon is a tissue that transmits force from muscle to bone. Chronic or acute tendon injuries
are very common, and are always accompanied by pain and a limited range of motion in …

Stepwise differentiation of mesenchymal stem cells augments tendon-like tissue formation and defect repair in vivo

Z Yin, J Guo, T Wu, X Chen, L Xu, S Lin… - Stem cells …, 2016 - academic.oup.com
Tendon injuries are common and present a clinical challenge, as they often respond poorly
to treatment and result in long-term functional impairment. Inferior tendon healing responses …

Multi-differentiation potential is necessary for optimal tenogenesis of tendon stem cells

I Rajpar, JG Barrett - Stem cell research & therapy, 2020 - Springer
Background Tendon injury is a significant clinical problem due to poor healing and a high
reinjury rate; successful treatment is limited by our poor understanding of endogenous …

Development of a refined tenocyte expansion culture technique for tendon tissue engineering

Y Qiu, X Wang, Y Zhang, AJ Carr, L Zhu… - Journal of tissue …, 2014 - Wiley Online Library
The aim of this study was to efficiently expand less differentiated tenocytes with minimum
use of fetal bovine serum (FBS) for tenocyte‐based tendon tissue engineering. To achieve …

The biophysical, biochemical, and biological toolbox for tenogenic phenotype maintenance in vitro

K Spanoudes, D Gaspar, A Pandit, DI Zeugolis - Trends in biotechnology, 2014 - cell.com
Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring
annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide …

Concise review: stem cell fate guided by bioactive molecules for tendon regeneration

YJ Zhang, X Chen, G Li, KM Chan… - Stem Cells …, 2018 - academic.oup.com
Tendon disorders, which are commonly presented in the clinical setting, disrupt the patients'
normal work and life routines, and they damage the careers of athletes. However, there is …

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair

V Citro, M Clerici, AR Boccaccini… - Journal of tissue …, 2023 - journals.sagepub.com
Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …

Directed differentiation and paracrine mechanisms of mesenchymal stem cells: potential implications for tendon repair and regeneration

B Zhang, Q Luo, A Halim, Y Ju… - Current Stem Cell …, 2017 - ingentaconnect.com
Background: Tendon is composed of connective tissue, is able to retract with high tensile
force, and plays a significant role in musculoskeletal motion. However, inappropriate …