Although platelet-derived growth factor receptor beta (PDGFR-β) mediates the recruitment of
vascular pericytes into ischemic lesion to restore the blood-brain barrier (BBB) dysfunction …

Pericytes, important elements of the blood-brain barrier (BBB), play critical roles in
maintaining BBB integrity and modulating hemostasis, angiogenesis, inflammation and …

Although platelet-derived growth factors (PDGFs) and receptors (PDGFRs) are abundantly
expressed in the central nervous system, their functions largely remain elusive. We …

Platelet derived growth factor (PDGF)-B plays a neuroprotective role in brain damages,
including ischemic stroke. It has been suggested recently that PDGF receptor β (PDGFRβ) …

Blood–brain barrier (BBB) dysfunction underlies the pathogenesis of many neurological
diseases. Platelet-derived growth factor receptor-alpha (PDGFRα) induces hemorrhagic …

Central nervous system (CNS) pericytes have been recognized as an indispensable
component of the neurovascular unit. The expression of platelet-derived growth factor …

The neuroprotective agents and induction of endogenous neurogenesis remain to be the
urgent issues to be established for the care of cerebral stroke. Platelet-derived growth factor …

Ischemic stroke causes blood–brain barrier (BBB) breakdown due to significant damage to
the integrity of BBB components. Recent studies have highlighted the importance of …

Pericytes, mural cells of brain capillaries, maintain the blood-brain barrier (BBB), regulate
cerebral blood flow (CBF), and protect neurons against ischemic damage. To further …

During cerebral ischemia, angiogenesis occurs inside and around the infarcted area. The
growth of new blood vessels may contribute to a better outcome after stroke due to …