MJ Romero, JA Iddings, DH Platt… - American Journal …, 2012 - journals.physiology.org
Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l- arginine and by increasing cell proliferation and collagen formation, which promote vascular …
CR Martens, JM Kuczmarski… - Journal of …, 2014 - journals.lww.com
Reduced nitric oxide bioavailability contributes to increased cardiovascular disease risk in patients with chronic kidney disease (CKD). Arginase has been implicated as a potential …
DE Berkowitz, R White, D Li, KM Minhas, A Cernetich… - Circulation, 2003 - Am Heart Assoc
Background—Although abnormal l-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …
S Ryoo, CA Lemmon, KG Soucy, G Gupta… - Circulation …, 2006 - Am Heart Assoc
Oxidized low-density lipoprotein (OxLDL) impairs NO signaling and endothelial function, and contributes to the pathogenesis of atherosclerosis. Arginase reciprocally regulates NO …
J Pernow, C Jung - Cardiovascular research, 2013 - academic.oup.com
Functional integrity of the vascular endothelium is of fundamental importance for normal vascular function. A key factor regulating endothelial function is the bioavailability of nitric …
Z Yang, XF Ming - Current hypertension reports, 2006 - Springer
Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction plays an important role in various cardiovascular disorders, including atherosclerosis …
W Shin, DE Berkowitz, S Ryoo - Experimental & molecular medicine, 2012 - nature.com
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired …
S Elms, F Chen, Y Wang, J Qian… - American Journal …, 2013 - journals.physiology.org
Reduced production of nitric oxide (NO) is one of the first indications of endothelial dysfunction and precedes overt cardiovascular disease. Increased expression of Arginase …