Defective host defenses later in life are associated with changes in immune cell activities,
suggesting that age-specific considerations are needed in immunotherapy approaches. In …

Defective host defenses later in life are associated with changes in immune system activity.
The means to correct immune defects to ensure immunity in the elderly are undefined. In this …

Aging is one of the biggest risk factors for cancer development. Over 85% of all cancers
occur in individuals aged over 55 years, often accompanied by age-associated immune …

Aging is associated with a decline in immune function, particularly within the T cell
compartment. Because CD8+ T cells are critical mediators of protective immunity against …

Progressive decline of the adaptive immune system with increasing age coincides with a
sharp increase in cancer incidence. In this study, we set out to understand whether deficits in …

Elixir for DCs | Nature Reviews Immunology Skip to main content Thank you for visiting
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CD8+ T cells play a central role in antitumor immune responses that kill cancer cells directly.
In aged individuals, CD8+ T cell immunity is strongly suppressed, which is associated with …

The etiology and effect of age-related immune dysfunction in cancer is not completely
understood. Here we show that limited priming of CD8+ T cells in the aged tumor …

It is known that immune system functions decrease with age, and that adaptive immune
responses, especially CD4+ T cell function, seem to be the main affected point in immunity …

We recently reported that bone marrow–derived dendritic cells (DC) from aged miced are
less effective than their young counterparts in inducing the regression of B16-ovalbumin …