Biological stoichiometry is the study of the balance of energy and multiple chemical
elements in biological systems. A key idea in biological stoichiometry is the growth rate …

Background A growing tumor in the body can be considered a complex ecological and
evolutionary system. A new eco-evolutionary hypothesis (the “Growth Rate Hypothesis” …

Tumors can be viewed as evolving ecological systems, in which heterogeneous populations
of cancer cells compete with each other and somatic cells for space and nutrients within the …

Many lines of evidence lead to the conclusion that ribosomes, and therefore phosphorus,
are potentially important commodities in cancer cells. Also, the population of cancer cells …

Background It has been known for close to a century that, on average, tumors have a
metabolism that is different from those found in healthy tissues. Typically, tumors show a …

Malignant transformation is often accompanied by significant metabolic changes. To identify
drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line …

Precision oncology is the practice of matching one therapy to one specific patient, based on
particular genetic tumor alterations, in order to achieve the best clinical response. Despite …

Background The study of cancer metabolism has been largely dedicated to exploring the
hypothesis that oncogenic transformation rewires cellular metabolism to sustain elevated …

Nutrients are indispensable resources that provide the macromolecular building blocks and
energy requirements for sustaining cell growth and survival. Cancer cells require several …

Intracellular processes rarely work in isolation but continually interact with the rest of the cell.
In microbes, for example, we now know that gene expression across the whole genome …