Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …
function differ, on average, between people with schizophrenia and healthy individuals. As …
[HTML][HTML] The genetic relationships between brain structure and schizophrenia
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …
structure but it has been unclear which genes are associated with both schizophrenia and …
[HTML][HTML] Boosting schizophrenia genetics by utilizing genetic overlap with brain morphology
D Van der Meer, AA Shadrin, K O'Connell, F Bettella… - Biological …, 2022 - Elsevier
Background Schizophrenia is a complex polygenic disorder with subtle, distributed
abnormalities in brain morphology. There are indications of shared genetic architecture …
abnormalities in brain morphology. There are indications of shared genetic architecture …
Brain heterogeneity in schizophrenia and its association with polygenic risk
Importance Between-individual variability in brain structure is determined by gene-
environment interactions, possibly reflecting differential sensitivity to environmental and …
environment interactions, possibly reflecting differential sensitivity to environmental and …
Genetic association between schizophrenia and cortical brain surface area and thickness
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …
variants, each with a small effect. While cortical differences between patients with …
[HTML][HTML] Grey and white matter microstructure is associated with polygenic risk for schizophrenia
Recent discovery of approximately 270 common genetic variants associated with
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity
BackgroundSchizophrenia is a complex mental disorder with high heritability and polygenic
inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of …
inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of …
Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in …
Patients with schizophrenia have consistently shown brain volumetric abnormalities,
implicating both etiological and pathological processes. However, the genetic relationship …
implicating both etiological and pathological processes. However, the genetic relationship …
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
AFT Van Scheltinga, SC Bakker, NEM Van Haren… - Biological …, 2013 - Elsevier
BACKGROUND: Thousands of common single nucleotide polymorphisms (SNPs) are
weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs …
weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs …