Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression
V Wahl-Jensen, S Kurz, F Feldmann… - PLoS neglected …, 2011 - journals.plos.org
Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV
primarily targets mononuclear phagocytes, which are activated upon infection and secrete …
primarily targets mononuclear phagocytes, which are activated upon infection and secrete …
Transcriptome analysis of circulating immune cell subsets highlight the role of monocytes in Zaire Ebola virus Makona pathogenesis
AR Menicucci, K Versteeg, C Woolsey… - Frontiers in …, 2017 - frontiersin.org
Existing models of Ebola virus disease (EVD) suggest antigen-presenting cells are initial
targets of Zaire ebolavirus (ZEBOV). In vitro studies have shown that ZEBOV infection of …
targets of Zaire ebolavirus (ZEBOV). In vitro studies have shown that ZEBOV infection of …
Molecular determinants of Ebola virus virulence in mice
H Ebihara, A Takada, D Kobasa, S Jones… - PLoS …, 2006 - journals.plos.org
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman
primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme …
primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme …
Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants
K Versteeg, AR Menicucci, C Woolsey, CE Mire… - Scientific reports, 2017 - nature.com
Zaire Ebolavirus (ZEBOV) continues to pose a significant threat to human health as
highlighted by the recent epidemic that originated in West Africa and the ongoing outbreak …
highlighted by the recent epidemic that originated in West Africa and the ongoing outbreak …
The role of mononuclear phagocytes in Ebola virus infection
KJ Rogers, W Maury - Journal of leukocyte biology, 2018 - academic.oup.com
Abstract The filovirus, Zaire Ebolavirus (EBOV), infects tissue macrophages (Mϕs) and
dendritic cells (DCs) early during infection. Viral infection of both cells types is highly …
dendritic cells (DCs) early during infection. Viral infection of both cells types is highly …
A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species-and cell-type-specific manner
O Martinez, E Ndungo, L Tantral, EH Miller… - Journal of …, 2013 - Am Soc Microbiol
Zaire Ebola virus (EBOV) is a zoonotic pathogen that causes severe hemorrhagic fever in
humans. A single viral glycoprotein (GP) mediates viral attachment and entry. Here, virus …
humans. A single viral glycoprotein (GP) mediates viral attachment and entry. Here, virus …
Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis
N Wauquier, P Becquart, C Padilla… - PLoS neglected …, 2010 - journals.plos.org
Background Ebolavirus species Zaire (ZEBOV) causes highly lethal hemorrhagic fever,
resulting in the death of 90% of patients within days. Most information on immune responses …
resulting in the death of 90% of patients within days. Most information on immune responses …
Ebola virus secreted glycoprotein decreases the anti-viral immunity of macrophages in early inflammatory responses
JH Bradley, A Harrison, A Corey, N Gentry… - Cellular immunology, 2018 - Elsevier
During Ebola virus (EBOV) infection, secreted glycoprotein (sGP) is found in large quantities
in the serum of both patients and infected animal models. It is thought to serve as a decoy for …
in the serum of both patients and infected animal models. It is thought to serve as a decoy for …
Early transcriptional changes within liver, adrenal gland, and lymphoid tissues significantly contribute to ebola virus pathogenesis in cynomolgus macaques
Ebola virus (EBOV) continues to pose a significant threat to human health, as evidenced by
the 2013–2016 epidemic in West Africa and the ongoing outbreak in the Democratic …
the 2013–2016 epidemic in West Africa and the ongoing outbreak in the Democratic …
High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon
P Becquart, N Wauquier, T Mahlakoiv, D Nkoghe… - PloS one, 2010 - journals.plos.org
To better understand Zaire ebolavirus (ZEBOV) circulation and transmission to humans, we
conducted a large serological survey of rural populations in Gabon, a country characterized …
conducted a large serological survey of rural populations in Gabon, a country characterized …