Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …

The hippocampus formation, although prominently implicated in schizophrenia
pathogenesis, has been overlooked in large-scale genomics efforts in the schizophrenic …

The chromatin landscape of human brain cells encompasses key information to
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …

Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …

To understand the pathological processes of schizophrenia, we must embrace the analysis
of the diseased human brain: we will never be able to recapitulate the pathology of uniquely …

Risk variants for schizophrenia affect more than 100 genomic loci, yet cell-and tissue-
specific roles underlying disease liability remain poorly characterized. We have generated …

Background While hybridization based analysis of the cortical transcriptome has provided
important insight into the neuropathology of schizophrenia, it represents a restricted view of …

Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The
pathophysiology of the illness is not understood, but is thought to have a strong genetic …