Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11

J Fedry, DL Hurdiss, C Wang, W Li, G Obal, I Drulyte… - Science …, 2021 - science.org
The emergence of SARS-CoV-2 antibody escape mutations highlights the urgent need for
broadly neutralizing therapeutics. We previously identified a human monoclonal antibody …

Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

TN Starr, AJ Greaney, AS Dingens, JD Bloom - Cell Reports Medicine, 2021 - cell.com
Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis
for coronavirus disease 2019 (COVID-19). However, ongoing evolution of severe acute …

Passive immunotherapy against SARS-CoV-2: from plasma-based therapy to single potent antibodies in the race to stay ahead of the variants

WR Strohl, Z Ku, Z An, SF Carroll, BA Keyt, LM Strohl - BioDrugs, 2022 - Springer
The COVID-19 pandemic is now approaching 2 years old, with more than 440 million people
infected and nearly six million dead worldwide, making it the most significant pandemic …

[HTML][HTML] Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

AJ Greaney, AN Loes, KHD Crawford, TN Starr… - Cell host & …, 2021 - cell.com
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-
mediated immunity. To facilitate prospective surveillance for such evolution, we map how …

[HTML][HTML] SARS-CoV-2 variants show resistance to neutralization by many monoclonal and serum-derived polyclonal antibodies

M Diamond, R Chen, X Xie, J Case, X Zhang… - Research …, 2021 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global
COVID-19 pandemic infecting more than 106 million people and causing 2.3 million deaths …

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

R Shi, C Shan, X Duan, Z Chen, P Liu, J Song, T Song… - Nature, 2020 - nature.com
An outbreak of coronavirus disease 2019 (COVID-19),–, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spread globally. Countermeasures are needed …

SARS-CoV-2 variants B. 1.351 and B. 1.1. 248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination

M Hoffmann, P Arora, R Groß, A Seidel, B Hörnich… - BioRxiv, 2021 - biorxiv.org
The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies
worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the …

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

R Rouet, JY Henry, MD Johansen, M Sobti… - Nature …, 2023 - nature.com
Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-
2 monoclonal antibodies and vaccines currently used in clinical practice; broadly …

Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Y Kaku, T Kuwata, HM Zahid, T Hashiguchi, T Noda… - Cell reports, 2021 - cell.com
Administration of convalescent plasma or neutralizing monoclonal antibodies (mAbs) is a
potent therapeutic option for coronavirus disease 2019 (COVID-19) caused by severe acute …

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Z Lv, YQ Deng, Q Ye, L Cao, CY Sun, C Fan, W Huang… - Science, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health …