Broadly-neutralizing antibodies against emerging SARS-CoV-2 variants
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
have become a major concern in the containment of current pandemic. The variants …
have become a major concern in the containment of current pandemic. The variants …
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal …
respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal …
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
T Li, W Xue, Q Zheng, S Song, C Yang, H Xiong… - Nature …, 2021 - nature.com
The emergence of numerous variants of SARS-CoV-2, the causative agent of COVID-19,
has presented new challenges to the global efforts to control the COVID-19 pandemic. Here …
has presented new challenges to the global efforts to control the COVID-19 pandemic. Here …
[HTML][HTML] COVID-19-neutralizing antibodies predict disease severity and survival
WF Garcia-Beltran, EC Lam, MG Astudillo, D Yang… - Cell, 2021 - cell.com
Summary Coronavirus disease 2019 (COVID-19) exhibits variable symptom severity ranging
from asymptomatic to life-threatening, yet the relationship between severity and the humoral …
from asymptomatic to life-threatening, yet the relationship between severity and the humoral …
In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains
Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures.
Although cell culture experiments have demonstrated a loss of potency of several anti-spike …
Although cell culture experiments have demonstrated a loss of potency of several anti-spike …
Structural basis of SARS-CoV-2 and SARS-CoV antibody interactions
E Gavor, YK Choong, SY Er, H Sivaraman… - Trends in …, 2020 - cell.com
The 2019 coronavirus pandemic remains a major public health concern. Neutralizing
antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here on severe acute …
antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here on severe acute …
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
Abstract Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2
(SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results …
(SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results …
Structures of SARS-CoV-2 B. 1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
Dear Editor, The spread of the SARS-CoV-2 variants, especially the global variants of
concern (VOCs), could seriously dampen our efforts to tackle the COVID-19 pandemic. The …
concern (VOCs), could seriously dampen our efforts to tackle the COVID-19 pandemic. The …
Receptor-binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2
Neutralization assays are experimental surrogates for the effectiveness of infection-or
vaccine-elicited polyclonal antibodies and therapeutic monoclonal antibodies targeting …
vaccine-elicited polyclonal antibodies and therapeutic monoclonal antibodies targeting …
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection
Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We
identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed …
identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed …