[HTML][HTML] Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

DL Burnett, KJL Jackson, DB Langley, A Aggarwal… - Immunity, 2021 - cell.com
Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy.
Second-generation vaccines will need to elicit neutralizing antibodies against sites that are …

[HTML][HTML] Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

R De Gasparo, M Pedotti, L Simonelli, P Nickl… - Nature, 2021 - nature.com
Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2
spike protein are among the most promising approaches against COVID-19,. A bispecific …

[HTML][HTML] Neutralizing monoclonal antibodies for treatment of COVID-19

PC Taylor, AC Adams, MM Hufford… - Nature Reviews …, 2021 - nature.com
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical …

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

E Rujas, I Kucharska, YZ Tan, S Benlekbir… - Nature …, 2021 - nature.com
Abstract SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic.
Antibodies can be powerful biotherapeutics to fight viral infections. Here, we use the human …

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

C Zhang, Y Wang, Y Zhu, C Liu, C Gu, S Xu… - Nature …, 2021 - nature.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutralizing antibodies against SARS …

Epitope classification and RBD binding properties of neutralizing antibodies against SARS-CoV-2 variants of concern

A Deshpande, BD Harris, L Martinez-Sobrido… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SAR-CoV-2) causes coronavirus disease
2019 (COVID19) that is responsible for short and long-term disease, as well as death, in …

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

W Li, Y Chen, J Prévost, I Ullah, M Lu, SY Gong… - Cell reports, 2022 - cell.com
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

L Zhang, L Cao, XS Gao, BY Zheng… - National Science …, 2021 - academic.oup.com
Mutations and transient conformational movements of the receptor binding domain (RBD)
that make neutralizing epitopes momentarily unavailable present immune escape routes for …

Protective neutralizing epitopes in SARS‐CoV‐2

H Liu, IA Wilson - Immunological reviews, 2022 - Wiley Online Library
The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

MA Tortorici, M Beltramello, FA Lempp, D Pinto… - Science, 2020 - science.org
Efficient therapeutic options are needed to control the spread of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of …