Functionalized carbon nanotubes specifically bind to α-chymotrypsin's catalytic site and regulate its enzymatic function

B Zhang, Y Xing, Z Li, H Zhou, Q Mu, B Yan - Nano letters, 2009 - ACS Publications
Although carbon nanotubes (CNTs) have been shown to nonspecifically bind proteins
through charge complementary, π− π stacking or hydrophobic interactions, they have not …

Inhibition of α-chymotrypsin by pristine single-wall carbon nanotubes: Clogging up the active site

M Di Giosia, TD Marforio, A Cantelli, F Valle… - Journal of colloid and …, 2020 - Elsevier
The preferred spatial orientation of single-wall carbon nanotubes (SWCNTs) in their
interaction with enzymes determines their behavior either as nano-supports or as inhibitors …

The devil and holy water: protein and carbon nanotube hybrids

M Calvaresi, F Zerbetto - Accounts of chemical research, 2013 - ACS Publications
Integrating carbon nanotubes (CNTs) with biological systems to form hybrid functional
assemblies is an innovative research area with great promise for medical, nanotechnology …

Influence of the surface functional group density on the carbon-nanotube-induced α-chymotrypsin structure and activity alterations

X Zhao, F Hao, D Lu, W Liu, Q Zhou… - ACS applied materials & …, 2015 - ACS Publications
Because of the special properties of carbon nanotubes (CNTs), their applications have been
introduced to many fields. The biosafety of these emerging materials is of high concern …

Structure and function of enzymes adsorbed onto single-walled carbon nanotubes

SS Karajanagi, AA Vertegel, RS Kane, JS Dordick - Langmuir, 2004 - ACS Publications
We have examined the structure and function of two enzymes, α-chymotrypsin (CT) and
soybean peroxidase (SBP), adsorbed onto single-walled carbon nanotubes (SWNTs). SBP …

Carbon nanotubes: a review on structure and their interaction with proteins

N Saifuddin, AZ Raziah, AR Junizah - Journal of Chemistry, 2013 - Wiley Online Library
Carbon nanotubes (CNTs) are allotropes of carbon with a nanostructure that can have a
length‐to‐diameter ratio greater than 1,000,000. Techniques have been developed to …

Electrostatics-mediated α-chymotrypsin inhibition by functionalized single-walled carbon nanotubes

D Zhao, J Zhou - Physical Chemistry Chemical Physics, 2017 - pubs.rsc.org
The α-chymotrypsin (α-ChT) enzyme is extensively used for studying nanomaterial-induced
enzymatic activity inhibition. A recent experimental study reported that carboxylized carbon …

Structure, function, and stability of enzymes covalently attached to single-walled carbon nanotubes

P Asuri, SS Bale, RC Pangule, DA Shah, RS Kane… - Langmuir, 2007 - ACS Publications
We describe the structure, activity, and stability of enzymes covalently attached to single-
walled carbon nanotubes (SWNTs). Conjugates of SWNTs with three functionally unrelated …

The potential impact of carboxylic-functionalized multi-walled carbon nanotubes on trypsin: A Comprehensive spectroscopic and molecular dynamics simulation study

M Noordadi, F Mehrnejad, RH Sajedi, M Jafari… - PLoS …, 2018 - journals.plos.org
In this study, we report a detailed experimental, binding free energy calculation and
molecular dynamics (MD) simulation investigation of the interactions of carboxylic …

Functionalization of carbon nanotubes for biocompatibility and biomolecular recognition

M Shim, NW Shi Kam, RJ Chen, Y Li, H Dai - Nano letters, 2002 - ACS Publications
The interface between biological molecules and novel nanomaterials is important to
developing new types of miniature devices for biological applications. Here, the …