The sudden increase in information derived from the completed Mycobacterium tuberculosis
(Mtb) genome sequences has revealed the need for approaches capable of converting raw …

Proteins of the 6-kDa early secreted antigenic target (ESAT-6) secretion system-1 of
Mycobacterium tuberculosis are not only strongly involved in the anti-mycobacterial Th1 …

Mycobacterium tuberculosis (Mtb) disrupts anti-microbial pathways of macrophages, cells
that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to …

We have previously shown that the secreted M. tuberculosis complex proteins CFP-10 and
ESAT-6 form a tight, 1: 1 complex, which may represent their functional form. In the work …

The Mycobacterium tuberculosis complex CFP-10/ESAT-6 family proteins play essential but
poorly defined roles in tuberculosis pathogenesis. In this article we report the results of …

The Snm protein secretion system is a critical determinant of Mycobacterium tuberculosis
virulence. However, genes encoding components of this pathway are conserved among all …

The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the
extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 …

Mycobacterium tuberculosis uses the ESX-1/Snm system [early secreted antigen 6
kilodaltons (ESAT-6) system 1/secretion in mycobacteria] to deliver virulence factors into …

In the present study, we demonstrate that, in analogy with the genes encoding ESAT-6 and
CFP-10, the genes rv0287 and rv0288 from the ESAT-6 gene family are cotranscribed …

The ESX‐1 secretion system of Mycobacterium tuberculosis delivers bacterial virulence
factors to host cells during infection. The most abundant factor, the ESAT‐6/CFP‐10 dimer, is …