Timing of antibiotic administration determines the spread of plasmid-encoded antibiotic resistance during microbial range expansion

Y Ma, J Ramoneda, DR Johnson - Nature Communications, 2023 - nature.com
Plasmids are the main vector by which antibiotic resistance is transferred between bacterial
cells within surface-associated communities. In this study, we ask whether there is an …

[HTML][HTML] Metabolic interactions control the transfer and spread of plasmid-encoded antibiotic resistance during surface-associated microbial growth

Y Ma, A Kan, DR Johnson - Cell Reports, 2024 - cell.com
Surface-associated microbial systems are hotspots for the spread of plasmid-encoded
antibiotic resistance, but how surface association affects plasmid transfer and proliferation …

Ecology determines how low antibiotic concentration impacts community composition and horizontal transfer of resistance genes

J Cairns, L Ruokolainen, J Hultman… - Communications …, 2018 - nature.com
Low concentrations of antibiotics have numerous effects on bacteria. However, it is unknown
whether ecological factors such as trophic interactions and spatial structuring influence the …

Plasmids persist in a microbial community by providing fitness benefit to multiple phylotypes

L Li, A Dechesne, JS Madsen, J Nesme… - The ISME …, 2020 - academic.oup.com
The current epidemic of antibiotic resistance has been facilitated by the wide and rapid
horizontal dissemination of antibiotic resistance genes (ARGs) in microbial communities …

The spread of antibiotic resistance is driven by plasmids amongst the fastest evolving and of broadest host range

C Coluzzi, EPC Rocha - bioRxiv, 2024 - biorxiv.org
Microorganisms endure novel challenges for which other microorganisms in other biomes
may have already evolved solutions. This is the case of nosocomial bacteria under antibiotic …

Interspecific competition can drive plasmid loss from a focal species in a microbial community

D Sünderhauf, U Klümper, WH Gaze… - The ISME …, 2023 - academic.oup.com
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, and
it is therefore critical to predict and reduce plasmid spread within microbial communities. The …

The dilution effect limits plasmid horizontal transmission in multispecies bacterial communities

A Kottara, L Carrilero, E Harrison, JPJ Hall… - …, 2021 - microbiologyresearch.org
By transferring ecologically important traits between species, plasmids drive genomic
divergence and evolutionary innovation in their bacterial hosts. Bacterial communities are …

Forecasting the dissemination of antibiotic resistance genes across bacterial genomes

MMH Ellabaan, C Munck, A Porse, L Imamovic… - Nature …, 2021 - nature.com
Antibiotic resistance spreads among bacteria through horizontal transfer of antibiotic
resistance genes (ARGs). Here, we set out to determine predictive features of ARG transfer …

Plasmid viability depends on the ecological setting of hosts within a multiplasmid community

C Given, R Penttinen, M Jalasvuori - Microbiology Spectrum, 2022 - Am Soc Microbiol
Plasmids are extrachromosomal genetic elements, some of which disperse horizontally
between different strains and species of bacteria. They are a major factor in the …

Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities

A Alonso-del Valle, R León-Sampedro… - Nature …, 2021 - nature.com
Plasmid persistence in bacterial populations is strongly influenced by the fitness effects
associated with plasmid carriage. However, plasmid fitness effects in wild-type bacterial …