The role of cytochrome P450 enzymes in COVID-19 pathogenesis and therapy
G Wang, B Xiao, J Deng, L Gong, Y Li, J Li… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has become a new public health crisis threatening
the world. Dysregulated immune responses are the most striking pathophysiological …
the world. Dysregulated immune responses are the most striking pathophysiological …
Role of cytochrome P450 2C9 in COVID-19 treatment: current status and future directions
The major human liver drug metabolising cytochrome P450 (CYP) enzymes are
downregulated during inflammation and infectious disease state, especially during …
downregulated during inflammation and infectious disease state, especially during …
Impact of SARS‐CoV‐2 infection (COVID‐19) on cytochromes P450 activity assessed by the Geneva cocktail
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) infection, is a severe acute respiratory syndrome with an …
coronavirus 2 (SARS‐CoV‐2) infection, is a severe acute respiratory syndrome with an …
Potential effects of COVID-19 on cytochrome P450-mediated drug metabolism and disposition in infected patients
S Deb, S Arrighi - European journal of drug metabolism and …, 2021 - Springer
Abstract Coronavirus Disease 2019 (COVID-19) has been a global health crisis since it was
first identified in December 2019. In addition to fever, cough, headache, and shortness of …
first identified in December 2019. In addition to fever, cough, headache, and shortness of …
Cytochrome P450-mediated drug interactions in COVID-19 patients: Current findings and possible mechanisms
At the end of 2019, the entire world has witnessed the birth of a new member of coronavirus
family in Wuhan, China. Ever since, the Severe Acute Respiratory Syndrome Coronavirus 2 …
family in Wuhan, China. Ever since, the Severe Acute Respiratory Syndrome Coronavirus 2 …
Variation in expression of cytochrome P450 3A isoforms and toxicological effects: endo-and exogenous substances as regulatory factors and substrates
C Fujino, S Sanoh, T Katsura - Biological and Pharmaceutical …, 2021 - jstage.jst.go.jp
The CYP3A subfamily, which includes isoforms CYP3A4, CYP3A5, and CYP3A7 in humans,
plays important roles in the metabolism of various endogenous and exogenous substances …
plays important roles in the metabolism of various endogenous and exogenous substances …
In vitro effect of Withania somnifera, AYUSH-64, and remdesivir on the activity of CYP-450 enzymes: Implications for possible herb−drug interactions in the …
Ayurvedic medicines Withania somnifera Dunal (ashwagandha) and AYUSH-64 have been
used for the prevention and management of COVID-19 in India. The present study explores …
used for the prevention and management of COVID-19 in India. The present study explores …
Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …
infection has become a global pandemic due to the high viral transmissibility and …
Physiologically based pharmacokinetic modelling to investigate the impact of the cytokine storm on CYP3A drug pharmacokinetics in COVID‐19 patients
F Stader, M Battegay, P Sendi… - Clinical Pharmacology & …, 2022 - Wiley Online Library
Patients with coronavirus disease 2019 (COVID‐19) may experience a cytokine storm with
elevated interleukin‐6 (IL‐6) levels in response to severe acute respiratory syndrome …
elevated interleukin‐6 (IL‐6) levels in response to severe acute respiratory syndrome …
COVID‐19 metabolism: Mechanisms and therapeutic targets
T Wang, Y Cao, H Zhang, Z Wang, CH Man… - MedComm, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral
signaling, immune response, and cell metabolism in human body. Viral genome and …
signaling, immune response, and cell metabolism in human body. Viral genome and …